BioScience2004 - from molecules to organisms
18-22 July 2004
SECC, Glasgow, UK

The Biochemical Society's first Flagship Meeting BioScience2004 was a huge success, with over 1200 delegates attending, 64 companies exhibiting, and more than 500 posters presented over 4 days.

This page is a short extract from the original event site.

Science Programme


Monday 19 July 2004


Focus Topics:
Lipids, Rafts and Traffic
(Including Biochemical Society Annual Symposium)

8:30-9:30 Plenary Lecture
Graham Warren (Yale, CT, USA)
Biogenesis of the Golgi apparatus
lecture supported by Science International
Speaker Abstract
Chair: Paul Luzio (Cambridge, UK)
9:30-10:00 Coffee/tea break

Biochemical Society Annual Symposium: 'Lipids, Rafts and Traffic'
Cell Trafficking, Protein 'out'

Biochemical Society Annual Symposium: 'Lipids, Rafts and Traffic'

Chairs
Nigel Hooper (Leeds, UK)
Jeff McIlhinney (Oxford, UK)
10:00-10:30 David Stephens (Bristol, UK)
Organization and regulation of COPII-mediated cargo export from the endoplasmic reticulum
Speaker Abstract
10:30-10:45 Selected poster presentation - Paula Urquhart (Leeds, UK)
N-Glycan dependant apical trafficking of a naturally N-glycosylated and GPI-anchored protein in polarised epithelial cells
Speaker Abstract
10:45-11:15 Rainer Duden (Cambridge Institute for Medical Research, Cambridge, UK)
COP I coat proteins in Golgi-to-ER traffic: functional domains and novel interactors
Speaker Abstract
11:15-11:45 Francis Barr (Max Planck Institute of Biochemistry, Martinsried, Germany)
Signalling at the Golgi apparatus
Speaker Abstract
11:45-12:00 Selected poster presentation - Ashley Toye (Bristol, UK)
Polarised trafficking of kidney anion exchanger 1 (kAE1) in MDCK cells
Speaker Abstract
12:00-12:30 Martin Lowe (Manchester, UK)
Phosphoinositide metabolism and protein trafficking at the Golgi apparatus
Speaker Abstract
12:30-14:30 Lunch and poster session

Biochemical Society Annual Symposium: 'Lipids, Rafts and Traffic'
Cell Trafficking, Protein 'in'

Biochemical Society Annual Symposium: 'Lipids, Rafts and Traffic'

Chairs
Nigel Hooper (Leeds, UK)
Jeff McIlhinney (Oxford, UK)
14:30-15:00 Oleg Glebov (MRC-LMB, Cambridge, UK)
Endocytosis and membrane organization of GPI-linked proteins
Speaker Abstract
15:00-15:15 Selected poster presentation - Karen Smillie (Edinburgh, UK)
Essential role for the phosphorylation of Dynamin I in synaptic vesicle endocytosis
Speaker Abstract
15:15-15:45 Elizabeth Smythe (Sheffield, UK)
Regulation of the clathrin coated vesicle cycle by reversible phosphorylation
Speaker Abstract
15:45-16:15 Coffee/tea break
16:15-16:45 Tom Kirchhausen (Harvard Medical School, Boston, MA, USA)
Single-molecule live cell imaging of clathrin-based endocytosis
Speaker Abstract
16:45-17:00 Selected poster presentation - Arwyn Jones (Cardiff, UK)
Multiple endocytic defects in cells expressing mutants of the small GTPase Rab21
Speaker Abstract
17:00-17:30 Paul Luzio (Cambridge Institute for Medical Research, Cambridge UK)
Membrane traffic to and from lysosomes
Speaker Abstract
17:45- Morton Lecture
Peter Parker (Cancer Research UK, London)
Phosphorylating proteins and lipids
Speaker Abstract
Chair: Philip Cohen (Dundee, UK)

Focus Topics:
Signalling Outwards and Inwards

8:30-9:30 Plenary Lecture
Graham Warren (Yale, CT, USA)
Biogenesis of the Golgi apparatus
lecture supported by Science International
Speaker Abstract
Chair: Paul Luzio (Cambridge, UK)
9:30-10:00 Coffee/tea break

Regulators of GPCR Specificity and GPCR Dimerization

Chairs
John Challiss (Leicester, UK)
Tim Palmer (Glasgow, UK)
10:00-10:30 Craig Malbon (State University of New York, Stony Brook, NY, USA)
GPCR specificity and spatial discrimination: doing more with less
Speaker Abstract
10:30-11:00 David Poyner (Aston, UK)
Heterodimers and family B GPCRS; RAMPs, CGRP and adrenomedullin
Speaker Abstract
11:00-11:15 Selected poster presentation - Debbie Hay (Auckland, New Zealand)
Pharmacological characterisation of the AMY1(a) receptor
Speaker Abstract
11:15-11:45 Jean-Phillipe Pin (CCIPE, Montpellier, France)
Class-III G-protein coupled receptors: why two subunits required?
Speaker Abstract
11:45-12:00 Selected poster presentation - Kate Lidwell (Southampton, UK)
Identification and characterisation of Group II mGluR-interacting proteins
Speaker Abstract
12:00-12:30 Joel Bockaert (Montpellier, France)
GPCR accessory proteins: discovery and functions
Speaker Abstract
12:30-14:30 Lunch and poster session
14:30-15:00 Graeme Milligan (Glasgow, UK)
The mechanisms and specificity of GPCR dimerisation
Speaker Abstract
15:00-15:15 Selected poster presentation - Virginie Binet (CNRS, Montpellier, France)
The heptaheptical domain of GABAB2 is directly activated by CGP7930, a positive allosteric modulator of the GABAB receptor
Speaker Abstract
15:15-15:45 Michel Bouvier (Montréal, Canada)
Oligomeric assembly of G protein-coupled receptor signalling modules
Speaker Abstract
15:45-16:15 Coffee/tea break
16:15-16:45 Lee Limbird (Nashville, TN, USA)
Arrestin's nemesis: spinophilin antagonizes arrestin functions in vitro and in vivo
Speaker Abstract
16:45-17:00 Selected poster presentation - Jonathan Willets (Leicester, UK)
Desensitization of M1 muscarinic acetylcholine receptor (mAChR) signalling by GRK2 in hippocampal neurones is phosphorylation-dependent
Speaker Abstract
17:00-17:30 Richard Neubig (Michigan, MI, USA)
Regulators of G protein signalling - multifunctional signal modulators
Speaker Abstract

Oncogenesis

Chair
Heather Wallace (Aberdeen, UK)
14:30-15:00 Walter Kolch (Beatson Institute, Glasgow, UK)
Regulation of oncogenic Raf signalling by RKIP
Speaker Abstract
15:00-15:15 Selected poster presentation - Shira Elhyany (BGU, Israel)
The integrity of cholesterol-enriched micro-domains is essential for the constitutive high activity of protein kinase B in tumor cells
Speaker Abstract
15:15-15:45 Chris Marshall (Institute of Cancer Research, London, UK)
Interplay between small GTPase signalling pathways in cancer
Speaker Abstract
15:45-16:15 Coffee/tea break
16:15-16:45 Margaret Frame (Beatson Institute, Glasgow UK)
Regulation and function of the Src/FAK pathway in transformation
Speaker Abstract
16:45-17:00 Selected poster presentation - Verity Emmans (Southampton, UK)
PPARgamma: A regulator of diverse cellular responses in childhood neuroblastoma
Speaker Abstract
17:00-17:30 Anton Berns (Netherlands Cancer Institute, Amsterdam, The Netherlands)
Mouse models for sporadic cancer
Speaker Abstract
17:45- Morton Lecture
Peter Parker (Cancer Research UK, London)
Phosphorylating proteins and lipids
Speaker Abstract
Chair: Philip Cohen (Dundee, UK)

Focus Topics:
Structure Related to Function: Molecules and Cells

8:30-9:30 Plenary Lecture
Graham Warren (Yale, CT, USA)
Biogenesis of the Golgi apparatus
lecture supported by Science International
Speaker Abstract
Chair: Paul Luzio (Cambridge, UK)
9:30-10:00 Coffee/tea break

Dynamic Imaging Techniques

Chair
Alan Entwistle (Ludwig Institute for Cancer Research, London, UK)
10:00-10:30 Philippe Bastiaens (EMBL, Heidelberg, Germany)
Ras acylation cycle specifies localization and activity
Speaker Abstract
10:30-10:45 Selected poster presentation - Andrew MacLean (Tulane, New Orleans, USA)
Chemokines and neuroinflammation modeled in vitro
Speaker Abstract
10:45-11:15 Daniel Choquet (Bordeaux, France)
Single molecule detection to follow receptor movements in living neurons
Speaker Abstract
11:15-11:45 Graham A. Dunn (Randall Institute, London, UK)
FLAP - a new method for studying protein dynamics in living cells
Speaker Abstract
11:45-12:00 To be confirmed
Speaker Abstract
12:00-12:30 Jason Swedlow (Dundee, UK)
A phosphorylation network at the mitotic centromere
Speaker Abstract
12:30-14:30 Lunch and poster session

Structure of Membrane Proteins

Chair
Parvez Haris (De Montfort, UK)
14:30-15:00 Tetsuji Okada (AIST, Tokyo, Japan)
X-ray crystallographic studies on ligand-protein interaction changes in rhodopsin
Speaker Abstract
15:00-15:15 Selected poster presentation - Kathryn Ferguson (Pennsylvania, USA)
Active and inactive conformations of the epidermal growth factor receptor
Speaker Abstract
15:15-15:45 Richard Cogdell (Glasgow, UK)
The structure and function of the light-harvesting complexes which make up the purple bacterial photosynthetic unit
Speaker Abstract
15:45-16:15 Coffee/tea break
16:15-16:45 So Iwata (Imperial College London, UK)
Structure of photosystem II and architecture of the oxygen evolving centre
Speaker Abstract
16:45-17:00 Selected poster presentation - Robert Ford (UMIST, UK)
Purification, crystallisation and structural analysis of CFTR
Speaker Abstract
17:00-17:30 Werner Kuelbrandt (Frankfurt, Germany)
Electron microscopy of membrane transport proteins
Speaker Abstract

Observing Single Molecules

Chair
Tony Cass (Imperial College London, UK)
14:30-15:00 D. Alastair Smith (Leeds, UK)
Mechanical unfolding of proteins
Speaker Abstract
15:00-15:30 Carlos Bustamante (Howard Hughes Medical Institute, Berkeley, CA, USA)
Grabbing the cat by the tail: studies of DNA packaging by single phi29 bacteriophage particles using optical tweezers
Speaker Abstract
15:30-15:45 Selected poster presentation - Yuji C. Sasaki (SPring-8/JASRI, Japan)
Single protein molecular dynamics determined with ultra-high precision
Speaker Abstract
15:45-16:15 Coffee/tea break
16:15-16:45 David Klenerman (Cambridge, UK)
Fluorescence studies of single biomolecules
Speaker Abstract
16:45-17:15 Ignacio Tinoco (Berkeley, CA, USA)
The effect of force on thermodynamics and kinetics: unfolding single RNA molecules
Speaker Abstract
17:45- Morton Lecture
Peter Parker (Cancer Research UK, London)
Phosphorylating proteins and lipids
Speaker Abstract
Chair: Philip Cohen (Dundee, UK)

Focus Topics:
Genes: Regulation, Processing and Interference

8:30-9:30 Plenary Lecture
Graham Warren (Yale, CT, USA)
Biogenesis of the Golgi apparatus
lecture supported by Science International
Speaker Abstract
Chair: Paul Luzio (Cambridge, UK)
9:30-10:00 Coffee/tea break

Nuclear RNA Splicing and Processing

Chair
Sheila Graham (Glasgow, UK)
10:00-10:30 Olga Makarova (Max Planck Institute of Biophysical Chemistry, Göttingen, Germany & Leicester, UK)
Structural dynamics and function of the mammalian spliceosome
Speaker Abstract
10:30-11:00 Andy Newman (MRC-LMB, Cambridge, UK)
Functional analysis of spliceosomal proteins in yeast
Speaker Abstract
11:00-11:30 Paula Grabowski (Howard Hughes Medical Institute, Pittsburgh, PA, USA)
Exon silencing by UAGG and GGGG motif patterns
Speaker Abstract
11:30-12:00 Chris Burge (Massachusetts Institute of Technology, Cambridge, MA, USA)
A census of sequences that silence splicing
Speaker Abstract

Cell Cycle Control

Chair
Alison Lloyd (University College London, UK)
10:00-10:30 Chris McInerny (Glasgow, UK)
Cell-cycle-regulated transcription in fission yeast
Speaker Abstract
10:30-10:45 Selected poster presentation - Natalie Carter (Glasgow, UK)
Dissection of the signalling mechanisms underlying FcgRIIb mediated apoptosis of mature B cells
Speaker Abstract
10:45-11:15 Brian Dynlacht (New York, USA)
Transcriptional control of the cell cycle
11:15-11:45 Kristian Helin (European Institute for Oncology, Milan, Italy)
Regulation of cell cycle progression by the E2F transcription factors
Speaker Abstract
11:45-12:00 Selected poster presentation - Pam Scott (Glasgow, UK)
Role of protein kinase C in the regulation of transcription by RNA polymerase III
Speaker Abstract
12:00-12:30 Stephen Taylor (Manchester, UK)
Bub1 and Aurora cooperate to maintain the spindle checkpoint
Speaker Abstract
12:30-14:30 Lunch and poster session
15:45-16:15 Coffee/tea break
17:45- Morton Lecture
Peter Parker (Cancer Research UK, London)
Phosphorylating proteins and lipids
Speaker Abstract
Chair: Philip Cohen (Dundee, UK)

Research Colloquia

8:30-9:30 Plenary Lecture
Graham Warren (Yale, CT, USA)
Biogenesis of the Golgi apparatus
lecture supported by Science International
Speaker Abstract
Chair: Paul Luzio (Cambridge, UK)
9:30-10:00 Coffee/tea break

Research Colloquium Lipidomics in Health and Disease: New Technologies in Lipid Analysis

Chair
Valerie O'Donnell (Cardiff, UK)
10:00-10:30 James Shepherd (Glasgow, UK)
Lipids in health and disease
Speaker Abstract
10:30-10:50 Selected Poster Presentation - Tony Postle (Southampton, UK)
Analysis of lipid dynamics by electrospray ionisation mass spectrometry
Speaker Abstract
10:50-11:05 Selected Poster Presentation - Neil Henderson (Southampton, UK)
Dynamics and molecular specificity of [methyl-D9] choline incorporation into liver and plasma phosphatidylcholine in mice
Speaker Abstract
11:05-11:20 Selected Poster Presentation - Kirstee Martin (Dundee, UK)
Identification of a Trypanosoma brucei phosphatidylinositol synthetase
Speaker Abstract
11:20-11:35 Selected Poster Presentation - Gavin Jewell (Southampton, UK)
Analysis of the molecular specificity of neutrophil phospholipase D by electrospray ionisation mass spectrometry
Speaker Abstract
11:35-11:50 Selected Poster Presentation - Jie Zhang (Liverpool, UK)
Lipid rafts, Ca signalling and contractility: an investigation in human uterus
Speaker Abstract
11:50-12:10 Selected Poster Presentation - Alan Hunt (Southampton, UK)
Lipidomic insights into cell phosphatidylcholine synthesis and intracellular lipid transport
Speaker Abstract
12:10-12:30 General discussion on Lipidomics in Health and Disease
12:30-14:30 Lunch and poster session

Research Colloquium Mitochondria in Health and Disease

Chair
Martin Brand (MRC Dunn Human Nutrition Unit, Cambridge, UK)
14:30-15:00 Anthony Schapira (Royal Free Hospital, London, UK)
Disorders of mitochondrial respiratory chain metabolism
Speaker Abstract
15:00-15:15 Selected Poster Presentation - Oi-Tong Mak (National Cheng Kung University, Taiwan)
Study of the prostaglandin receptors in mitochondria on apoptosis of human lung carcinoma cell line A549
Speaker Abstract
15:15-15:30 Selected Poster Presentation - Meredith Ross (MRC Dunn Human Nutrition Unit, Cambridge, UK)
Cell-penetrating peptides as vectors for delivery to mitochondria
Speaker Abstract
15:30-15:45 Selected Poster Presentation - Konstantin Lyamzaev (Moscow State University, Russia)
Selective elimination of mitochondria from living cell induced by inhibitors of bioenergetic functions
Speaker Abstract
15:45-16:15 Coffee/tea break
16:15-16:30 Selected Poster Presentation - Carolyn Wiltshire (Glasgow, UK)
Functional characterisation of a novel JNK-interacting protein
Speaker Abstract
16:30-16:45 Selected Poster Presentation - Thilo Hagen (Nottingham, UK)
Inhibition of mitochondrial respiration by the anticancer agent 2-methoxyestradiol and its consequences for HIF1astabilisation and cellular ROS production
Speaker Abstract
16:45-17:00 Selected Poster Presentation - Richard Porter (Trinity College Dublin, Ireland)
Identification of a functioning mitochondrial uncoupling protein 1 in rat thymus
Speaker Abstract
17:00-17:15 Selected Poster Presentation - Palwinder Mander (Cambridge, UK)
Inflammatory-activated microglia kill co-cultured neurons via nitric oxide and peroxynitrite
Speaker Abstract

Research Colloquium Mechanisms of Gene Regulation

Chair
Michael Schweizer (Heriot-Watt, UK)
14:30-15:00 Nicholas Proudfoot (Oxford, UK)
Interconnecting transcriptional elongation and termination with messenger RNA processing in eukaryotes
Speaker Abstract
15:00-15:12 Selected Poster Presentation - Abigail Lapham (Southhampton, UK)
Transcriptional control of Nramp1: a paradigm for the repressive action of C-MYC gene activation by MIZ-1
Speaker Abstract
15:12-15:24 Selected Poster Presentation - Kirsteen Campbell (Dundee, UK)
Active repression of anti-apoptotic gene expression by RelA(p65) NF-kB induced by cytotoxic stimuli
Speaker Abstract
15:24-15:36 Selected Poster Presentation - Stuart Rushworth (MRC-LMB, Cambridge, UK)
Lipopolysaccharide-induced haem oxygenase-1 expression in human monocytic cells is mediated by Nrf2
Speaker Abstract
15:36-15:48 Selected Poster Presentation - Adam West (Glasgow, UK)
The recruitment of histone modifications necessary for the barrier activity of the HS4 insulator
Speaker Abstract
15:45-16:15 Coffee/tea break
16:15-16:27 Selected Poster Presentation - Ansar Choudhry (Aberdeen, UK)
In vitro regulation of reporter gene transcription by the androgen receptor AF1 domain
Speaker Abstract
16:27-16:39 Selected Poster Presentation - Jane Plumb (Glasgow, UK)
Epigenetic approaches to cancer therapy
Speaker Abstract
16:39-16:51 Selected Poster Presentation - David Nelson (Liverpool, UK)
NF-kB transcription factor oscillations control the dynamics of target gene transcription
Speaker Abstract
16:51-17:03 Selected Poster Presentation - Francisco Dos Ramos (Cambridge, UK)
Characterisation of the SARS coronavirus 1a/1b ribosomal frameshifting signal
Speaker Abstract
17:03-17:15 Selected Poster Presentation - Laura Elsby (Manchester, UK)
Functional analysis of the N terminus of the general transcription factor (GTF) TFIIB
Speaker Abstract
17:15-17:27 Selected Poster Presentation - Mark Cuff (Liverpool, UK)
The importance of butyrate transport to the regulation of gene expression in the colonic epithelium
Speaker Abstract
17:45- Morton Lecture
Peter Parker (Cancer Research UK, London)
Phosphorylating proteins and lipids
Speaker Abstract
Chair: Philip Cohen (Dundee, UK)

Tuesday 20 July 2004


Focus Topics:
Lipids, Rafts and Traffic
(Including Biochemical Society Annual Symposium)

8:30-9:30 Plenary Lecture
Karen Vousden (Beatson Institute, Glasgow, UK)
Regulation of the p53 tumour suppressor protein
Chair: Peter Parker (Cancer Research UK, London)
9:30-10:00 Coffee/tea break

Biochemical Society Annual Symposium: 'Lipids, Rafts and Traffic'
Lipid Rafts in Neuronal Function

Biochemical Society Annual Symposium: 'Lipids, Rafts and Traffic'

Chairs
Nigel Hooper (Leeds, UK)
Jeff McIlhinney (Oxford, UK)
10:00-10:30 Claudia Stuermer (Konstanz, Germany)
The "lipid raft" microdomain proteins reggie-1 and reggie-2 are scaffolds for protein interaction and signalling
Speaker Abstract
10:30-10:45 Selected poster presentation - Anja Becher (Oxford, UK)
GABA(B) receptor constitutively associates with lipid rafts
Speaker Abstract
10:45-11:15 Pico Caroni (Basel, Switzerland)
Plasmalemmal rafts and actin regulation in neurons
Speaker Abstract
11:15-11:45 Carlos G. Dotti (Turin, Italy)
Neuronal Detergent-Resistant Membrane (DRM) domains take part in the control of amyloid peptide degradation and generation efficacy
Speaker Abstract
11:45-12:00 Selected poster presentation - Eva Janas (GlaxoSmithKline, UK)
Rituxan-induced relocalization and oligomerisation of the CD20 into lipid rafts
Speaker Abstract
12:00-12:30 Giampietro Schiavo (Cancer Research UK, London)
Specialised lipid rafts and retrograde axonal transport in motor neurons
Speaker Abstract
12:30-14:30 Lunch and poster session

Biochemical Society Annual Symposium: 'Lipids, Rafts and Traffic'
Lipid Biophysics (and Lipid-Protein) at the Molecular Level

Biochemical Society Annual Symposium: 'Lipids, Rafts and Traffic'

Chairs
Nigel Hooper (Leeds, UK)
Jeff McIlhinney (Oxford, UK)
14:30-15:00 Felix Goni (Bilbao, Spain)
Biophysics (and sociology) of ceramides
Speaker Abstract
15:00-15:15 Selected poster presentation - Teresa Pinheiro (Warwick, UK)
Aggregation of fibrillization of prions in lipid membranes
Speaker Abstract
15:15-15:45 Richard Templer (Imperial College London, UK)
Staying alive: how do cell's regulate lipid membrane composition?
Speaker Abstract
15:45-16:15 Coffee/tea break
16:15-16:45 Stuart McLaughlin (State University of New York, Stony Brook, NY, USA)
Calmodulin-mediated reversible sequestration of PIP2 by clusters of basic residues on plasma membrane proteins MARCKS, GAP43, and EGFR
Speaker Abstract
16:45-17:00 Selected poster presentation - Jennifer Gallop (MRC-LMB, Cambridge, UK)
Molecular mechanism of endophilin membrane binding and synaptojanin recruitment
Speaker Abstract
17:00-17:30 Paula Booth (Bristol, UK)
Exploiting lipid interactions to control membrane-protein insertion, folding and stability
Speaker Abstract
17:45- Biochemical Society Award Lecture
David Lane (Dundee, UK)
25 years of p53
Speaker Abstract
Chair: Chris Leaver (Oxford, UK)

Focus Topics:
Signalling Outwards and Inwards

8:30-9:30 Plenary Lecture
Karen Vousden (Beatson Institute, Glasgow, UK)
Regulation of the p53 tumour suppressor protein
Chair: Peter Parker (Cancer Research UK, London)
9:30-10:00 Coffee/tea break

PI 3-kinase in the Immune System

Chair
Melanie Welham (Bath, UK)
10:00-10:30 Doreen Cantrell (Dundee, UK)
The role of Phosphoinositide 3-kinases (PI3Ks) and Phosphoinositide dependent kinase 1 (PDK1) in T lymphyocytes
Speaker Abstract
10:30-10:45 Selected poster presentation - Barbara Hebeis (Babraham Institute, Cambridge, UK)
The p110d subunit of PI3K is required for the LPS response in mouse B cells
Speaker Abstract
10:45-11:15 Martin Turner (Babraham Institute, Cambridge, UK)
p110d regulates B cell development and activation
Speaker Abstract
11:15-11:45 Gerry Krystal (British Columbia Cancer Research Center, Vancouver, Canada)
The role of SHIP in haemopoietic cells
Speaker Abstract
11:45-12:00 Selected poster presentation - Khaled Ali (Ludwig Institute for Cancer Research, London, UK)
Essential role for p110d phosphoinositide 3-kinase in the allergic response
Speaker Abstract
12:00-12:30 Phillip Hawkins (Babraham Institute, Cambridge, UK)
Signalling via PI3 kinases
Speaker Abstract
12:30-14:30 Lunch and poster session
15:45-16:15 Coffee/tea break
17:45- Biochemical Society Award Lecture
David Lane (Dundee, UK)
25 years of p53
Speaker Abstract
Chair: Chris Leaver (Oxford, UK)

Focus Topics:
Structure Related to Function: Molecules and Cells

8:30-9:30 Plenary Lecture
Karen Vousden (Beatson Institute, Glasgow, UK)
Regulation of the p53 tumour suppressor protein
Chair: Peter Parker (Cancer Research UK, London)
9:30-10:00 Coffee/tea break

Ubiquitination (Structural Aspects)

Chair
John Mayer (Nottingham, UK)
10:00-10:30 Chris Hill (Utah, USA)
Proteasome activation: opening the gate
Speaker Abstract
10:30-10:45 Selected poster presentation - Robert Layfield (Nottingham, UK)
Structural and functional studies of mutations affecting the UBA domain of SQSTM1 (p62) which cause Paget's disease of bone
Speaker Abstract
10:45-11:15 Lori Passmore (Institute of Cancer Research, London, UK)
Structural and functional studies of the anaphase-promoting complex (APC)
Speaker Abstract
11:15-11:45 Cecile Pickart (Johns Hopkins, MD, USA)
Function and recognition of polyubiquitin signals
Speaker Abstract
11:45-12:00 Selected poster presentation - Lori Frappier (Toronto, Canada)
Structural studies on USP7/HAUSP Interactions with EBNA1 and p53
Speaker Abstract
12:00-12:30 Hartmut Vodermaier (Research Institute of Molecular Pathology, Vienna, Austria)
Architecture and functions of the APC: a molecular jigsaw puzzle
Speaker Abstract
12:30-14:30 Lunch and poster session

Cell Trafficking at the Structural (Atomic) Level

Chair
Mike Cousin (Edinburgh, UK)
14:30-15:00 Axel Brunger (Howard Hughes Medical Institute, Stanford, CA, USA)
Structural studies of proteins involved in membrane fusion
Speaker Abstract
15:00-15:15 Selected poster presentation - Natalia Beglova (Harvard, MA, USA)
Structural features of the LDL receptor facilitating ligand release at low pH
Speaker Abstract
15:15-15:45 Paul Freemont (Imperial College London, UK)
Understanding the function of the ancient AAA ATPase p97/CDC48/VCP in mediating membrane fusion and ER protein degradation: a combined structural biology approach
Speaker Abstract
15:45-16:15 Coffee/tea break
16:15-16:45 Marijn Ford (MRC-LMB, Cambridge, UK)
Clathrin-coated pit assembly
16:45-17:00 Selected poster presentation - Andrew Parker (Cambridge, UK)
Targeting of inositol 1,4,5-trisphosphate receptors to the endoplasmic reticulum by multiple signals within their transmembrane domains
Speaker Abstract
17:00-17:30 Harvey McMahon (MRC-LMB, Cambridge, UK)
Membrane bending and curvature sensing in clathrin-mediated endocytosis
Speaker Abstract
17:45- Biochemical Society Award Lecture
David Lane (Dundee, UK)
25 years of p53
Speaker Abstract
Chair: Chris Leaver (Oxford, UK)

Focus Topics:
Genes: Regulation, Processing and Interference

8:30-9:30 Plenary Lecture
Karen Vousden (Beatson Institute, Glasgow, UK)
Regulation of the p53 tumour suppressor protein
Chair: Peter Parker (Cancer Research UK, London)
9:30-10:00 Coffee/tea break

DNA Repair and Checkpoints

Chairs
Jon Sayers (morning) (Sheffield, UK)
Anne Willis (afternoon) (Leicester, UK)
10:00-10:30 Steve West (Cancer Research UK, London)
Efficient homologous recombination and the maintenance of genome stability
Speaker Abstract
10:30-10:45 Selected poster presentation - Hocine Mankouri (Cancer Research UK, Oxford)
Investigating the physiological role of the Sgs1p helicase
Speaker Abstract
10:45-11:15 Penny Jeggo (Sussex, UK)
DNA non-homologous end-joining and its link with ATM signalling
Speaker Abstract
11:15-11:45 Josef Jiricny (Institute of Molecular Cancer Research, Zürich, Switzerland)
Role of the mismatch repair system in DNA damage signalling
Speaker Abstract
11:45-12:00 Selected poster presentation - Chris West (Leeds, UK)
Arabidopsis DNA double strand break repair pathways
Speaker Abstract
12:00-12:30 Noel Lowndes (Galway, Ireland)
Recruitment of the budding yeast Rad9 protein to damaged DNA
Speaker Abstract
12:30-14:30 Lunch and poster session
14:30-15:00 Alan Ashworth (Institute of Cancer Research, London, UK)
Therapeutic exploitation of the DNA repair defects in BRCA mutant tumours
Speaker Abstract
15:00-15:15 Selected poster presentation - Thomas Helleday (Sheffield, UK)
Specific killing of BRCA2 deficient cells by inhibitors of poly(ADP-ribose) polymerase
Speaker Abstract
15:15-15:45 Simon Boulton (Cancer Research UK, London)
Cebrc-2 is essential for the repair of meiotic and radiation-induced breaks in C. elegans
15:45-16:15 Coffee/tea break
16:15-16:45 Jiri Bartek (Institute of Cancer Biology, Copenhagen, Denmark)
DNA damage checkpoints and their cancer-predisposing defects
16:45-17:00 Selected poster presentation - Grigory Dianov (MRC Radiation and Genome Stability Unit, Oxford, UK)
Protein dynamics on damaged DNA during base excision repair in human cell extracts
Speaker Abstract
17:00-17:30 Steve Jackson (Wellcome Trust/Cancer Research UK Institute of Cancer and Developmental Biology, Cambridge, UK)
Early events in the DNA-damage response
Speaker Abstract
17:45- Biochemical Society Award Lecture
David Lane (Dundee, UK)
25 years of p53
Speaker Abstract
Chair: Chris Leaver (Oxford, UK)

Focus Topics:
Energy: Generation and Information

8:30-9:30 Plenary Lecture
Karen Vousden (Beatson Institute, Glasgow, UK)
Regulation of the p53 tumour suppressor protein
Chair: Peter Parker (Cancer Research UK, London)
9:30-10:00 Coffee/tea break

Nutrient Interaction with Gene Expression

Joint Colloquium with the Nutrition Society

Chairs
John Arthur (Rowett Research Institute, Aberdeen, UK)
Philip Newsholme (University College Dublin, Ireland)
10:00-10:30 Christine Williams (Reading, UK)
Triglyceride-rich lipoprotein gene interactions in endothelial cells
Speaker Abstract
10:30-10:45 Selected poster presentation - Richard Ogborne (Cambridge, UK)
Nrf2 mediates a lipoic acid-induced haem oxygenase-1 expression in THP-1 monocytes
Speaker Abstract
10:45-11:15 Helen Roche (Dublin, Ireland)
Dietary lipids and gene expression
Speaker Abstract
11:15-11:45 Nick Wareham (Cambridge, UK)
Unravelling gene-environment interactions in type 2 diabetes
Speaker Abstract
11:45-12:00 Selected poster presentation - Jill McKay (Newcastle upon Tyne, UK)
Effect of folate depletion during pregnancy and suckling upon DNA methylation in murine adult offspring
Speaker Abstract
12:00-12:30 Heidi Kiil Blomhoff (Oslo, Norway)
Vitamin A regulates proliferation and apoptosis of T-cells via IL-2
Speaker Abstract
12:30-14:30 Lunch and poster session
14:30-15:00 John Bertram (Hawaii, USA)
Dietary carotenoids, connexins and cancer: what is the connection?
Speaker Abstract
15:00-15:15 Selected poster presentation - Janice Drew (Rowett Research Institute, ABERDEEN, UK)
Deregulation of collagen a1(I) and lysyl oxidase gene expression in vitamin E-depleted colon
Speaker Abstract
15:15-15:45 John Hesketh (Newcastle upon Tyne, UK)
3' untranslated regions are important in mRNA localization and translation - lessons from selenium and metallothionein
Speaker Abstract
15:45-16:15 Coffee/tea break
16:15-16:45 Malcolm Jackson (Liverpool, UK)
Oxidants, antioxidants and modification of gene expression
Speaker Abstract
16:45-17:00 Selected poster presentation - Irene Yeung (Southampton, UK)
Oxidant regulation of Nramp1 via Sp1
Speaker Abstract
17:00-17:30 Pascal Ferré (INSERM, Paris, France)
Regulation of hepatic genes by nutrients. A role for SREBP-1c
Speaker Abstract
17:45- Biochemical Society Award Lecture
David Lane (Dundee, UK)
25 years of p53
Speaker Abstract
Chair: Chris Leaver (Oxford, UK)

Focus Topics:
Ethics, Education and Employment

8:30-9:30 Plenary Lecture
Karen Vousden (Beatson Institute, Glasgow, UK)
Regulation of the p53 tumour suppressor protein
Chair: Peter Parker (Cancer Research UK, London)
9:30-10:00 Coffee/tea break
12:30-14:30 Lunch and poster session

Bioethics and Finance: Who Calls the Tune?

Chair
Robert Freedman (Warwick, UK)
14:30-15:00 Ian Gibson, MP (House of Commons, Science and Technology Select Committee.)
Funding and its importance in directing research
Speaker Abstract
15:00-15:30 Stephen Minger (King's College, London, UK)
Human embryonic stem cells
Speaker Abstract
15:45-16:15 Coffee/tea break
16:15-16:45 Mike Gale (John Innes Centre, Norwich, UK)
A place for GM breeding in developing country agriculture?
Speaker Abstract
16:45-17:15 John Sulston/Des Spence (The Sanger Centre, Hinxton, UK/GP, Glasgow, UK)
The equitable application of genomics

Ethics and Intellectual Property

'Ethics and Intellectual Property' will be a lunch time interactive session.

Focus of the session:
Ethics - e.g. tissue samples
What is patenting
Ethics of patenting

Chair
John Coggins (Glasgow, UK)
12:45-13:15 Angus MacLeod (Wright, Johnston and Mackenzie LLP, UK)
Ethics and intellectual property: the commercial lawyer?s perspective
Speaker Abstract
13:15-13:45 Graeme Laurie (Edinburgh, UK)
The ethics of patenting stem cell technologies
Speaker Abstract
13:45-14:15 Nick Bassil (Kilburn and Strode, UK)
Exclusions to patentability and developing practice at European Patent Office
Speaker Abstract
15:45-16:15 Coffee/tea break
17:45- Biochemical Society Award Lecture
David Lane (Dundee, UK)
25 years of p53
Speaker Abstract
Chair: Chris Leaver (Oxford, UK)

Research Colloquia

8:30-9:30 Plenary Lecture
Karen Vousden (Beatson Institute, Glasgow, UK)
Regulation of the p53 tumour suppressor protein
Chair: Peter Parker (Cancer Research UK, London)
9:30-10:00 Coffee/tea break

GPCR Signalling and Regulation - sponsored by Pfizer

(incorporating the GPCR-ion channel interactions Research Colloquium and Pfizer prize presentations)

Chairs
Michel Bouvier (Montreal, Canada)
Graeme Milligan (Glasgow, UK)
10:00-10:40 Fang Liu (Toronto, Canada)
Direct protein-protein interactions enable functional cross-talk between NMDA and dopamine D1 receptors
Speaker Abstract
10:40-10:55 Selected poster presentation (Pfizer prize entrant) - Patricia Viard (University College London, UK)
Phosphatidylinositol 3 Kinase enhances the trafficking of functional Cav/b2 channels to the plasma membrane
Speaker Abstract
10:55-11:10 Selected poster presentation (Pfizer prize entrant) - Amy Benians (University College London, UK)
Preferential regulation of G-protein activation by RGS8 is indicative of complex interactions
Speaker Abstract
11:10-11:50 Cristina Missale (Brescia, Italy)
Oligomeric assembly of dopamine D1 and glutamate NMDA receptors: molecular mechanisms and functional implications
Speaker Abstract
11:50-12:30 Yu Tian Wang (British Columbia, Canada)
Physical and functional crosstalk between Dopamine D5 and GABA-A receptors
Speaker Abstract
12:30-14:30 Lunch and poster session
14:30-15:15 Cornelius Krasel (Wuerzburg, Germany)
The kinetics of G-protein-coupled receptor signalling and desensitization
15:15-15:30 Selected poster presentation (Pfizer prize entrant) - Paula Bartlett (Leicester, UK)
Profiling of M3 and a1B receptor-mediated phospholipase C activation using single-cell ?biosensors?
Speaker Abstract
15:30-15:45 Selected poster presentation - (Pfizer prize entrant) - Natalie Strudwick (Leeds, UK)
Evidence to support a spectrum of receptor active states
Speaker Abstract
15:45-16:15 Coffee/tea break
16:15-16:30 Selected poster presentation (Pfizer prize entrant) - Rama Kamesh Bikkavilli (The Chinese University of Hong Kong, Shatin, NT, Hong Kong)
Identification of surrogate peptide ligands for rat mas protooncogene using phage-displayed random peptide library
Speaker Abstract
16:30-16:45 Selected poster presentation (Pfizer prize entrant) - Zoe Lawson (Birmingham, UK)
The role of the third extracellular loop of the vasopressin V1a receptor; a G-protein-coupled receptor
Speaker Abstract
16:45-17:30 Stephen Ferguson (Robarts Research Institute, London, ON, Canada)
Regulation of GPCR endocytosis, trafficking and signalling by small G proteins
Speaker Abstract
17:45- Biochemical Society Award Lecture
David Lane (Dundee, UK)
25 years of p53
Speaker Abstract
Chair: Chris Leaver (Oxford, UK)

Wednesday 21 July 2004


Focus Topics:
Lipids, Rafts and Traffic
(Including Biochemical Society Annual Symposium)

8:30-9:30 Plenary Lecture
Anthony Pawson (Toronto, Canada)
Modular protein-protein interactions in cell regulation
Speaker Abstract
Chair: Peter Downes (Dundee, UK)
9:30-10:00 Coffee/tea break

Translocation Across the Endoplasmic Reticulum
Membrane and Protein Folding in the Lumen of the Endoplasmic Reticulum

Chairs
Neil Bulleid (Manchester, UK)
Stephen High (Manchester, UK)
10:00-10:30 Art Johnson (Texas A&M, USA)
BiP-dependent gating of the aqueous ER translocon pore
Speaker Abstract
10:30-10:45 Selected poster presentation - Ben Abell (Manchester, UK)
Posttranslational targeting of tail-anchored proteins to the ER
Speaker Abstract
10:45-11:15 Stephen High (Manchester, UK)
Membrane protein synthesis and quality control at the endoplasmic reticulum
Speaker Abstract
11:15-11:45 Neil Bulleid (Manchester, UK)
Oxidative folding in the endoplasmic reticulum
Speaker Abstract
11:45-12:00 Selected poster presentation - Rob van Nues (Newcastle upon Tyne, UK)
Mutational analysis of the S.cerevisiae signal recognition particle RNA reveals a minimal core that interacts with non-essential variable regions
Speaker Abstract
12:00-12:30 Lars Ellgaard (Institute of Biochemistry, Zurich, Switzerland)
Chaperone systems for protein folding and oxidation in the endoplasmic reticulum
Speaker Abstract
12:30-14:30 Lunch and poster session

Molecular Control of Immune Synapses

Chair
Klaus Okkenhaug (Babraham Institute, Cambridge, UK)
14:30-15:00 Abraham Kupfer (National Jewish Medical and Research Center, Denver, CO, USA)
Imaging T cell activation in SMACs
15:00-15:15 Selected poster presentation - Oleg Glebov (Cambridge, UK)
Lipid raft proteins have a random distribution during localized activation of the T-cell receptor
Speaker Abstract
15:15-15:45 Mike Dustin (Skirball Institute of Biomolecular Medicine, New York, NY, USA)
The immunological synapse balances activation and tolerance
Speaker Abstract
15:45-16:15 Coffee/tea break
16:15-16:45 Ron Germain (National Institutes of Health, Bethesda, MD, USA)
Visualizing cell interactions during adaptive immune responses
Speaker Abstract
16:45-17:00 Selected poster presentation - Dagmar Scheel-Toellner (Birmingham, UK)
Clustering of death receptors in lipid rafts initiates neutrophil spontaneous apoptosis
Speaker Abstract
17:00-17:30 Daniel Davis (Imperial College London, UK)
Intercellular communication at human natural killer cell immune synapses
Speaker Abstract
17:45- Colworth Medal Lecture
James Naismith (St Andrews, UK)
Chemical insights from structural studies of enzymes
Speaker Abstract
Chair: Mike Ferguson (Dundee, UK)

Focus Topics:
Signalling Outwards and Inwards

8:30-9:30 Plenary Lecture
Anthony Pawson (Toronto, Canada)
Modular protein-protein interactions in cell regulation
Speaker Abstract
Chair: Peter Downes (Dundee, UK)
9:30-10:00 Coffee/tea break

b-Catenin/Wnt Signalling

Chair
Adrian Harwood (University College London, UK)
10:00-10:30 Paul Polakis (Genentech Inc, CA, USA)
Wnt signalling and breast cancer
Speaker Abstract
10:30-10:45 Selected poster presentation - Krishna Balakrishnan (Kings College London, UK)
The role and regulation of wisps during chondrogenesis
Speaker Abstract
10:45-11:15 Hsien-yu Wang (State University of New York, Stony Brook, NY, USA)
Frizzleds, G-proteins, and gene profiling: new insights into Wnt action
Speaker Abstract
11:15-11:45 Bill Weis (Stanford, CA, USA)
Mechanism of phosphorylation-dependent binding of APC Coli to b-catenin
Speaker Abstract
11:45-12:00 Selected poster presentation - Eva Martin (National University of Ireland, Galway)
Plakoglobin expression and localization in zebrafish embryo development
Speaker Abstract
12:00-12:30 Laurence Pearl (Institute of Cancer Research, London, UK)
Structure, specificity and regulation of Gsk3b?
Speaker Abstract
12:30-14:30 Lunch and poster session

GSK-3b in Neuronal Function

Chair
Calum Sutherland (Dundee, UK)
14:30-15:00 Trevor Dale (Institute of Cancer Research , London, UK)
Scaffolding of reactions involving GSK-3
Speaker Abstract
15:00-15:15 Selected poster presentation - Thilo Hagen (Nottingham, UK)
Regulation of Wnt signalling by the GSK-3 interacting proteins FRAT and LANA
Speaker Abstract
15:15-15:45 Selected poster presentation - Philip Gordon-Weeks (King's College London, UK)
The MAP kinase pathway activates GSK3b stimulating the phosphorylation of MAP1B and axon growth
Speaker Abstract
15:45-16:15 Coffee/tea break
16:15-16:45 Peter Klein (Pennsylvania, PA, USA)
GSK-3 as a neuronal target of lithium action in behaviour and neurodegenerative disorders
Speaker Abstract
16:45-17:00 Adrian Harwood (MRC, University College London, UK)
A molecular cell biology of lithium
Speaker Abstract
17:00-17:30 Jim Woodgett (Ontario Cancer Institute, Toronto, Canada)
Physiological functions of Glycogen Synthase Kinase-3 a and b
Speaker Abstract
17:45- Colworth Medal Lecture
James Naismith (St Andrews, UK)
Chemical insights from structural studies of enzymes
Speaker Abstract
Chair: Mike Ferguson (Dundee, UK)

Focus Topics:
Structure Related to Function: Molecules and Cells

8:30-9:30 Plenary Lecture
Anthony Pawson (Toronto, Canada)
Modular protein-protein interactions in cell regulation
Speaker Abstract
Chair: Peter Downes (Dundee, UK)
9:30-10:00 Coffee/tea break
12:30-14:30 Lunch and poster session

Signalling Lipid-Protein Interactions (Structural)

Chair
Dario Alessi (Dundee, UK)
14:30-15:00 Mark Lemmon (Philadelphia, PA, USA)
Membrane recruitment by pleckstrin homology domains
Speaker Abstract
15:00-15:15 Selected poster presentation - Hilary Roberts (Cambridge, UK)
Regulation of phosphatidylinositol 5-phosphate levels in cells
Speaker Abstract
15:15-15:45 Daan van Aalten (Dundee, UK)
Structural insights into the regulation of PDK1 by phosphoinositides and inositolphosphates
Speaker Abstract
15:45-16:15 Coffee/tea break
16:15-16:45 Jim Hurley (National Institutes of Health, Bethesda, MD, USA)
Structural mechanisms for signalling and sorting at membranes
Speaker Abstract
16:45-17:00 Selected poster presentation - Nelson Gekara (GBF, Braunschweig, Germany )
Lipid rafts aggregation and signalling by listeriolysin O
Speaker Abstract
17:00-17:30 Roger Williams (Cambridge, UK)
Recognition of inositol lipids versus inositol phosphates
Speaker Abstract
17:45- Colworth Medal Lecture
James Naismith (St Andrews, UK)
Chemical insights from structural studies of enzymes
Speaker Abstract
Chair: Mike Ferguson (Dundee, UK)

Focus Topics:
Genes: Regulation, Processing and Interference

8:30-9:30 Plenary Lecture
Anthony Pawson (Toronto, Canada)
Modular protein-protein interactions in cell regulation
Speaker Abstract
Chair: Peter Downes (Dundee, UK)
9:30-10:00 Coffee/tea break

Transcription Regulation in Development and Signalling

Chairs
Stefan Roberts (Manchester, UK)
Andy Sharrocks (Manchester, UK)
10:00-10:30 Stefan Roberts (Manchester, UK)
Transcriptional regulation by the Wilms' tumour suppressor protein WT1
Speaker Abstract
10:30-10:45 Selected poster presentation - David Lancaster (Oxford, UK)
The role of post-translational hydroxylation in eukaryotic oxygen sensing
Speaker Abstract
10:45-11:15 Richard Treisman (Cancer Research UK, London)
Signal convergence at the serum response element
Speaker Abstract
11:15-11:45 Neil Perkins (Dundee, UK)
Regulation of NF-kB function by tumour suppressors and oncogenes
Speaker Abstract
11:45-12:00 Selected poster presentation - Hugh Campbell (ANU, Australia)
The Gelsolin-related flightless I protein is involved in intracellular signalling
Speaker Abstract
12:00-12:30 Caroline Hill (Cancer Research UK, London)
Signalling to the nucleus by members of the TGF-b superfamily
Speaker Abstract

RNAi, How it Works, and its Use as a Technology

Chairs
Darcey Black (Organon, UK)
Sarah Newbury (Oxford, UK)
10:00-10:30 Phil Zamore (Massachusetts Medical School, MA, USA)
Asymmetric assembly of the RNAi enzyme complex
Speaker Abstract
10:30-11:00 Alan Herr (John Innes Centre, Norwich, UK)
RNA silencing in Arabidopsis
Speaker Abstract
11:00-11:30 Gino Poulin (Cambridge, UK)
Genome-wide RNAi screens in C. elegans
Speaker Abstract
11:30-12:00 Michael Boutros (German Cancer Research Center, Heidelberg, Germany)
Genome-wide cell based RNAi screens in Drosophila
Speaker Abstract
12:00-12:30 Martin Gorovsky (Rochester, NY, USA )
RNAi in genome rearrangement and centromere function in Tetrahymena
Speaker Abstract
12:30-14:30 Lunch and poster session
14:30-15:00 Bryan Williams (Lerner Research Institute, Cleveland, OH, USA)
Activation of the interferon system by siRNAs
Speaker Abstract
15:00-15:30 Traci Hall (NIEHS, Research Triangle Park, NC, USA)
siRNA measures up: crystal structure and binding specificity of an RNA silencing suppressor
Speaker Abstract
15:30-15:45 Selected poster presentation - Colin Dolphin (Kings College London, UK)
RNAi in human primary cells via recombinant baculoviral vectors
Speaker Abstract
15:45-16:15 Coffee/tea break
16:15-16:45 Jo Milner (York, UK)
RNA interference, viruses and cancer
Speaker Abstract
16:45-17:15 Thijn Brummelkamp (Netherlands Cancer Institute, Amsterdam, The Netherlands)
Large-scale RNAi screens to identify cancer relevant genes
Speaker Abstract
17:45- Colworth Medal Lecture
James Naismith (St Andrews, UK)
Chemical insights from structural studies of enzymes
Speaker Abstract
Chair: Mike Ferguson (Dundee, UK)

Focus Topics:
Energy: Generation and Information

8:30-9:30 Plenary Lecture
Anthony Pawson (Toronto, Canada)
Modular protein-protein interactions in cell regulation
Speaker Abstract
Chair: Peter Downes (Dundee, UK)
9:30-10:00 Coffee/tea break

Redox and Transfer of Information

Chair
Mike Murphy (MRC-Dunn Human Nutrition Unit, Cambridge, UK)
10:00-10:30 Toren Finkel (National Institutes of Health, Bethesda, MD, USA)
Signal transduction by oxygen radicals
Speaker Abstract
10:30-10:45 Selected poster presentation - Nick Leslie (Dundee, UK)
Redox regulation of phosphatase function
Speaker Abstract
10:45-11:15 Claude Piantadosi (Duke, Durham, NC, USA)
Redox control of mitochondrial biogenesis
Speaker Abstract
11:15-11:45 Dean Jones (Emory, GA, USA)
Thiol-disulphide redox in signalling and control
Speaker Abstract
11:45-12:00 Selected poster presentation - Gregory Giles (Alabama, Birmingham, USA)
Reactive sulphur species in oxidative signal transduction
Speaker Abstract
12:00-12:30 Mike Murphy (MRC-Dunn Human Nutrition Unit, Cambridge, UK)
Investigating mitochondrial radical production using targeted probes
Speaker Abstract
12:30-14:30 Lunch and poster session

Control and Sensing of Metabolism

Chair
Richard Reece (Manchester, UK)
14:30-15:00 David Fell (Oxford Brookes, UK)
Why are metabolite concentrations so stable?
Speaker Abstract
15:00-15:15 Selected poster presentation - Stefano Vavassori (Heriot-Watt , Edinburgh, UK)
The interaction of Slt2 MAP kinase with members of the Prs protein family is essential for proper signal transduction through the cell wall integrity pathway in Saccharomyces cerevisiae
Speaker Abstract
15:15-15:45 Martin Brand (Cambridge, UK)
Up-regulation of metabolism and the new uncoupling proteins
Speaker Abstract
15:45-16:15 Coffee/tea break
16:15-17:00 Paul Greenhaff (Nottingham,UK)
Integration of mitochondrial and cytosolic energy delivery at the onset of contraction in skeletal muscle
Speaker Abstract
17:00-17:30 Matthew Andrews (Minnesota, USA)
Genes controlling the metabolic switch in hibernating mammals
Speaker Abstract
17:45- Colworth Medal Lecture
James Naismith (St Andrews, UK)
Chemical insights from structural studies of enzymes
Speaker Abstract
Chair: Mike Ferguson (Dundee, UK)

Research Colloquia

8:30-9:30 Plenary Lecture
Anthony Pawson (Toronto, Canada)
Modular protein-protein interactions in cell regulation
Speaker Abstract
Chair: Peter Downes (Dundee, UK)
9:30-10:00 Coffee/tea break

Research Colloquium Control of Cell Motility

Chairs
Rob Insall (Birmingham, UK)
Anne Ridley (Ludwig Institute for Cancer Research, London, UK)
10:00-10:30 A. Rick Horwitz (Virginia, VA, USA)
Adhesion organization and dynamics during cell migration
Speaker Abstract
10:30-10:50 Selected Poster Presentation - Hitoshi Yagisawa (University of Hyogo, Japan)
A PLCd1-binding protein, p122RhoGAP, is localized in focal adhesions
Speaker Abstract
10:50-11:10 Selected Poster Presentation - Samantha Passey (Bristol, UK)
Regulation of the Actin Cytoskeleton by the Rho GTPase, Rif
Speaker Abstract
11:10-11:30 Selected Poster Presentation - Bee Leng Lua (National University of Singapore, Singapore)
BPGAP1 interacts with cortactin and facilitates its translocation to cell periphery for enhanced cell migration
Speaker Abstract
11:30-11:50 Selected Poster Presentation - Aleksander Ivetic (University College London, UK)
ERM proteins regulate microvillar positioning of L-selectin and leukocyte capture from flow
Speaker Abstract
11:50-12:10 Selected Poster Presentation - Simone Blagg (Birmingham, UK)
Control of SCAR activity in Dictyostelium discoideum
Speaker Abstract
12:10-12:30 Selected Poster Presentation - Jake Malone (Oxford, UK)
Functional analysis of WspR, a GGDEF response regulator
Speaker Abstract
12:30-14:30 Lunch and poster session
15:45-16:15 Coffee/tea break
17:45- Colworth Medal Lecture
James Naismith (St Andrews, UK)
Chemical insights from structural studies of enzymes
Speaker Abstract
Chair: Mike Ferguson (Dundee, UK)

Thursday 22 July 2004


Focus Topics:
Lipids, Rafts and Traffic
(Including Biochemical Society Annual Symposium)

8:30-9:30 Plenary Lecture
Stephen O'Rahilly (Cambridge, UK)
Human obesity and insulin resistance: lessons from experiments of nature
Speaker Abstract
Chair: Michael Czech (Massachusetts, MA, USA)
9:30-10:00 Coffee/tea break

Cellular Motors

Chair
George Banting (Bristol, UK)
10:00-10:30 John Kendrick-Jones (MRC-LMB, Cambridge, UK)
Myosin VI: a multifunctional motor
Speaker Abstract
10:30-10:45 Selected poster presentation - Bjørn Gilbert Nielsen (DTU, Denmark)
Towards bridging the gap from molecular forces to the movement of organisms
Speaker Abstract
10:45-11:15 Jon Scholey (Davis, CA, USA)
Intraflagellar transport motors in the C. elegans nervous system
Speaker Abstract
11:15-11:45 Nobutaka Hirokawa (Tokyo, Japan)
Kinesin superfamily proteins, KIFs and intracellular transport: dynamics, structure and functions
Speaker Abstract
11:45-12:00 Selected poster presentation - Kanamarlapudi Venkateswarlu (Bristol, UK)
Centaurin-a1 interacts directly with a novel kinesin like motor protein
Speaker Abstract
12:00-12:30 Michelle Peckham (Leeds, UK)
Imaging molecular motors in cells
12:30-13:30 Lunch and poster session

m-RNA and Protein Synthesis Localization

Chair
Chris Connolly (Dundee, UK)
13:30-14:00 Anne Ephrussi (EMBL, Heidelberg, Germany)
Splicing-dependent assembly of the oskar mRNA localization complex
Speaker Abstract
14:00-14:15 Selected poster presentation - Herve Chabanon (Newcastle upon Tyne, UK)
Characterisation of the cis-acting element directing perinuclear localization of the Metallothionein-1 mRNA
Speaker Abstract
14:15-14:45 Ilan Davis (Wellcome Trust Centre for Cell Biology, Edinburgh, UK)
The mechanism of transport and anchoring of mRNA in Drosophila
Speaker Abstract
14:45-15:15 Bernard Roizman (Chicago, IL, USA)
Posttranscriptional regulation of cellular mRNAs by herpes simplex virus 1 (HSV-1)
Speaker Abstract
15:15-15:30 Selected poster presentation - Ian Mickleburgh (Newcastle, UK)
Isolation and identification of a protein binding to the localization element of metallothionein-1 mRNA
Speaker Abstract
15:30-16:00 Jim Eberwine (Pennsylvania, PA, USA)
Dendritic molecular biology: mRNA transport, protein synthesis and a few surprises
Speaker Abstract
16:00-17:00 The EMBO Lecture
Christopher Dobson (Cambridge, UK)
Protein misfolding and its links with human disease
Speaker Abstract
Chair: John Coggins (Glasgow, UK)

Focus Topics:
Signalling Outwards and Inwards

8:30-9:30 Plenary Lecture
Stephen O'Rahilly (Cambridge, UK)
Human obesity and insulin resistance: lessons from experiments of nature
Speaker Abstract
Chair: Michael Czech (Massachusetts, MA, USA)
9:30-10:00 Coffee/tea break

Insulin Signalling

Chair
Ken Siddle (Cambridge, UK)
10:00-10:30 Dominic Withers (University College London, UK)
Insulin signalling: from the b cell to the brain
Speaker Abstract
10:30-11:00 Yehiel Zick (Weizmann Institute of Science, Israel)
Insulin resistance: a phosphorylation based uncoupling of insulin signalling
Speaker Abstract
11:00-11:30 Dario Alessi (Dundee, UK)
Functional analysis of PDK1 signalling pathway using knockout and knockin approaches
Speaker Abstract
11:30-12:00 Jeremy Tavare (Bristol, UK)
Insulin action: phosphorylation and compartmentalization
Speaker Abstract
12:00-12:30 Mike Czech (Massachusetts Medical School, Worcester, MA, USA)
Analysis of insulin signalling through siRNA-based gene silencing
Speaker Abstract

Integrins, Structure and Function

Chairs
Martin Humphries (Manchester, UK)
Robert Liddington (Burnham Institute, La Jolla, CA, USA)
10:00-10:30 Tim Springer (Harvard, MA, USA)
Dramatic conformational changes and bidirectional signalling across membranes in integrins
Speaker Abstract
10:30-10:45 Selected poster presentation - Alexandre Gingras (Nottingham, UK)
Structural studies of the interaction between the cytoskeletal proteins talin and vinculin
Speaker Abstract
10:45-11:15 Robert Liddington (Burnham Institute, La Jolla, CA, USA)
Structural studies of the integrin-cytoskeleton linkage
Speaker Abstract
11:15-11:45 Mark Ginsberg (Scripps Institute, La Jolla, CA, USA)
Integrin signalling from the inside
Speaker Abstract
11:45-12:00 Selected poster presentation - Annarosa Arcangeli (Firenze, Italy)
b1 integrin and HERG1 potassium channels form a macromolecular complex involved in cell signalling
Speaker Abstract
12:00-12:30 Martin Humphries (Manchester, UK)
A specific a5b1 integrin conformation promotes directional integrin translocation and fibronectin matrix formation
Speaker Abstract
12:30-13:30 Lunch and poster session

Complexity of Adhesion Contacts

Chair
Clare Isacke (Institute of Cancer Research, London, UK)
13:30-14:00 Benny Geiger (Weizmann Institute of Science, Israel)
The molecular dynamics of cell adhesion
14:00-14:15 Selected poster presentation - Wolfgang Ziegler (Braunschweig, Germany)
Vinculin involvement in lipid regulation of adhesion site turnover
Speaker Abstract
14:15-14:45 David Critchley (Leicester, UK)
Talin, vinculin and focal adhesions
Speaker Abstract
14:45-15:15 Keith Burridge (North Carolina, USA)
Signalling from adhesion to Rho family GTPases
Speaker Abstract
15:15-15:30 Selected poster presentation - Jan Wijnholds (Netherlands Ophthalmic Research Institute, Amsterdam, The Netherlands)
Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure
Speaker Abstract
15:30-16:00 Laura Machesky (Birmingham, UK)
Signalling to actin assembly: the IRSp53/MIM connection
Speaker Abstract
16:00-17:00 The EMBO Lecture
Christopher Dobson (Cambridge, UK)
Protein misfolding and its links with human disease
Speaker Abstract
Chair: John Coggins (Glasgow, UK)

Focus Topics:
Structure Related to Function: Molecules and Cells

8:30-9:30 Plenary Lecture
Stephen O'Rahilly (Cambridge, UK)
Human obesity and insulin resistance: lessons from experiments of nature
Speaker Abstract
Chair: Michael Czech (Massachusetts, MA, USA)
9:30-10:00 Coffee/tea break

Ribosomes and Chaperones (Structure)

Chair
Mick Tuite (Kent, UK)
10:00-10:30 Wolfgang Wintermeyer (Witten/Herdecke, Germany)
What ribosome structure tells about function - and vice versa
Speaker Abstract
10:30-11:00 Selected poster presentation - Tobias von der Haar (UMIST, UK)
Novel conformations of initiating yeast 40S ribosomal subunits
Speaker Abstract
11:00-11:30 Keith Willison (Institute of Cancer Research, London, UK)
Regulation and function of eukaryotic cytosolic chaperonin, CCT
Speaker Abstract
11:30-12:00 Helen Saibil (Birkbeck College, London, UK)
Structure and mechanism of GroE chaperonins
Speaker Abstract
12:00-12:30 Laurence Pearl (Institute of Cancer Research, London, UK)
Structure and function of the Hsp90 molecular chaperone
Speaker Abstract
12:30-13:30 Lunch and poster session

Proteomics of Macromolecular Complexes

Chair
Ian Fearnley (Cambridge, UK)
13:30-14:00 Archa Fox (Dundee, UK)
New insights into nuclear organization revealed by proteomic analysis of human nucleoli
Speaker Abstract
14:00-14:15 Selected poster presentation - Agnieszka Chacinska (Freiburg, Germany)
The mitochondrial protein import machineries - organization, dynamics and cooperation
Speaker Abstract
14:15-14:45 Anne-Claude Gavin (Cellzome AG, Germany)
Drug proteomics
Speaker Abstract
14:45-15:15 Peter McPherson (McGill, Quebec, Canada)
Molecular mechanisms in clathrin-mediated membrane budding revealed through subcellular proteomics
Speaker Abstract
15:15-15:30 Selected poster presentation - Petr Pompach (Krc, Prague, Czech Republic )
Identification of proteins associated with lipid rafts of Jurkat T-cell line by mass spectrometry
Speaker Abstract
15:30-16:00 Seth Grant (Edinburgh, UK)
Organization of the synapse proteome
Speaker Abstract

Glycosylation

Chair
Tony Corfield (Bristol, UK)
13:30-14:00 Pauline Rudd (Oxford, UK)
Sugar recognition, protein folding and defence
Speaker Abstract
14:00-14:15 Selected poster presentation - Ondrej Plihal (Charles University, Prague, Czech Republic)
N-glycosylated catalytic unit meets O-glycosylated propeptide: complex protein architecture in fungal hexosaminidase
Speaker Abstract
14:15-14:45 Ten Feizi (Imperial College London, UK)
Oligosaccharide microarrays to decipher the glyco code
Speaker Abstract
14:45-15:15 Paul Crocker (Dundee, UK)
Sialic acid binding Ig-like lectins (siglecs) in the immune system
Speaker Abstract
15:15-15:30 Selected poster presentation - Deuan Jones (Dundee, UK)
The N-glycan glucosidase system in Trypanosoma brucei
Speaker Abstract
15:30-16:00 Melitta Schachner (Hamburg, Germany)
Structure and function of glycans mediating cell recognition in the mammalian nervous system
Speaker Abstract
16:00-17:00 The EMBO Lecture
Christopher Dobson (Cambridge, UK)
Protein misfolding and its links with human disease
Speaker Abstract
Chair: John Coggins (Glasgow, UK)

Focus Topics:
Genes: Regulation, Processing and Interference

8:30-9:30 Plenary Lecture
Stephen O'Rahilly (Cambridge, UK)
Human obesity and insulin resistance: lessons from experiments of nature
Speaker Abstract
Chair: Michael Czech (Massachusetts, MA, USA)
9:30-10:00 Coffee/tea break

Chromatin and Gene Regulation

Chairs
Iain McEwan (Aberdeen, UK)
Bob White (Glasgow, UK)
10:00-10:30 Jerry Workman (Stowers Institute for Medical Research, Missouri, USA )
Analysis of protein complexes that modify chromatin
Speaker Abstract
10:30-10:45 Selected poster presentation - Katherine West (University of Glasgow, Scotland, UK)
Chromosomal proteins HMGN3a and HMGN3b regulate the expression of glycine transporter 1
Speaker Abstract
10:45-11:15 Craig Peterson (Massachusetts, USA)
Chromatin remodelling: regulators of transcription and DNA repair
Speaker Abstract
11:15-11:45 Jane Mellor (Oxford, UK)
Regulation of transcription elongation by histone methylation, histone acetylation and chromatin remodelling ATPases
Speaker Abstract
11:45-12:00 Selected poster presentation - Rosalie Waldron (Biosciences Institute, Cork, Ireland)
Complex regulation and nuclear localization of JRK protein
Speaker Abstract
12:00-12:30 Jean Pierre Quivy (Institut Curie, Paris, France)
Chromatin assembly factor 1 (CAF-1) is involved in a specific architecture for heterochromatin duplication in mouse cells.
Speaker Abstract
12:30-13:30 Lunch and poster session
13:30-14:00 Tony Kouzarides (Wellcome/Cancer Research UK , Cambridge)
Role of histone modifications in chromatin function and cancer
Speaker Abstract
14:00-14:15 Selected poster presentation - Gordon Strathdee (Glasgow, UK)
Genes with cell type specific DNA methylation patterns in normal tissue exhibit novel patterns of histone modifications
Speaker Abstract
14:15-14:45 Ronen Marmorstein (Wistar Institute, PA, USA)
Structure and chemistry of the Sir2 family of NAD+-dependent histone/protein deactylases
Speaker Abstract
14:45-15:15 Peter Jones (USC/Norris Comprehensive Cancer Center, CA, USA)
The epigenetics of human cancer
Speaker Abstract
15:15-15:30 Selected poster presentation - Robert Brown (Glasgow, UK)
Aberrant methylation at pro-apoptotic genes in ovarian cancer is associated with clinical outcome
Speaker Abstract
15:30-16:00 Ron Hay (St Andrews, UK)
The role of SUMO modification in transcriptional regulation
Speaker Abstract
16:00-17:00 The EMBO Lecture
Christopher Dobson (Cambridge, UK)
Protein misfolding and its links with human disease
Speaker Abstract
Chair: John Coggins (Glasgow, UK)

Research Colloquia

8:30-9:30 Plenary Lecture
Stephen O'Rahilly (Cambridge, UK)
Human obesity and insulin resistance: lessons from experiments of nature
Speaker Abstract
Chair: Michael Czech (Massachusetts, MA, USA)
9:30-10:00 Coffee/tea break
12:30-13:30 Lunch and poster session

Research Colloquium Proteins Acting at or in Membranes: Structure and Function Update

Chair
Mike Sutcliffe (Leicester, UK)
13:30-14:00 Neil Isaacs (Glasgow, UK)
Crystal structures of membrane proteins: some approaches and some results
Speaker Abstract
14:00-14:15 Selected Poster Presentation - Ian Collinson (MPI-Biophysik, Germany)
Structure and function of a protein-conducting channel
Speaker Abstract
14:15-14:30 Selected Poster Presentation - Josef Wissler (ARCONS Institute for Applied Research & Didactics, Germany)
Encephalopathic neuronal [prion] proteins, transfer factors of delayed-type hypersensitivity [DTH] and transmissible proteinaceous infection: structural relations in protein folding and domains for binding redox- and metalloregulated nucleic acid bioaptam
Speaker Abstract
14:30-14:45 Selected Poster Presentation - Jiri Pavlicek (Charles University Prague, Czech Republic)
Lymphocyte activation receptor: new structural paradigms in the group V of C-type animal lectins
Speaker Abstract
14:45-15:00 Selected Poster Presentation - William Gilmore (Ulster, UK)
Annexin II expression during cellular differentiation in myeloid cell lines
Speaker Abstract
15:00-15:15 Selected Poster Presentation - Allison Cox (Maine, Orono, ME, USA)
The cacophony gene and courtship song: GAL4-driven expression of UAS-cac in Drosophila melanogaster
Speaker Abstract
15:15-15:30 Selected Poster Presentation - Jillian Madine (UMIST, UK)
The relationship between membrane binding and aggregation of alpha-synuclein peptides
Speaker Abstract
15:30-15:45 Selected Poster Presentation - Jon Sayers (Sheffield, UK)
Molecular structure and processing of the IgA protease, a type V autotransporter
Speaker Abstract
16:00-17:00 The EMBO Lecture
Christopher Dobson (Cambridge, UK)
Protein misfolding and its links with human disease
Speaker Abstract
Chair: John Coggins (Glasgow, UK)

Poster Abstracts

Focus Topic: Lipids, Rafts and Traffic(Including Biochemical Society Annual Symposium)

A101-A123 - Biochemical Society Annual Symposium: Cell Trafficking, Protein 'out'

Monday 19 July, 12:30-14:30
A101 Regulation of ER export by PCTAIRE protein kinases
K.J. Palmer, J. Konkel and D.J. Stephens
A102 Polarity of leukemia inhibitory factor secretion
E. Hill and A.B. Vernallis
A103 The role of amisyn and tomosyn in the regulation of exocytosis
J.R.L. Constable, A. Morgan and R.D. Burgoyne
A104 Centaurin-a1 is an in vivo PIP3-dependent GAP for ARF6 that is involved in actincytoskeleton organization
K. Venkateswarlu, K.G. Brandom and J.L. Lawrence
A105 IPCEF1 interacts with and potentiates cytohesin 2 activity
K. Venkateswarlu
A106 Apical sorting and lipid raft association of the influenza A virus nucleoprotein
M. Carrasco and P. Digard
A107 Linking secretion and polarity in the early C. elegans embryo
R. Andrews, N. Le Bot and J. Ahringer
A108 Trafficking of NMDA receptor subunits
M. Garside, P. Wingrove, P. Whiting and R.A.J. McIlhinney
A109 Lipid rafts and the regulation of exocytosis
C. Salaün and L.H. Chamberlain
A110 The transcriptional repressor REST coordinates the regulated secretory pathway
A.W. Bruce, A. Krejci, L. Ooi, J. Deuchars, I.C. Wood, V. Dolezal and N.J. Buckley
A111 Polarised trafficking of kidney anion exchanger 1 (kAE1) in MDCK cells
A.M. Toye and G. Banting
A112 Interaction of NCS-1 and ARF-1 to modulate lipid kinase activity
L.P. Haynes, G. Thomas and R.D. Burgoyne
A113 A direct organelle proteomic approach to identify new Golgi proteins
T. Maarit and R. Ragna
A114 Coupling of ER exit to microtubules through the interaction of COPII with dynactin
P. Watson, K.J. Palmer and D.J. Stephens
A115 Calcium pump modulators, phospholamban and sarcolipin: targeting to and retention by theendoplasmic reticulum
J. Butler, A.G. Lee, M.F. Cuttle and J.M. East
A116 ER localisation of the chloride channel ClC-4 is mediated by a novel N-terminal ER targeting motif
H. Okkenhaug, C.F. Higgins and A. Sardini
A117 Syntaxins 16 in regulated membrane traffic
K.M. Proctor, N.J. Bryant and G.W. Gould
A118 Localisation of certain budded virus surface glycoproteins in baculovirus-infected cells occurs within lipid raft domains at the plasma membrane
F.J. Haines, A.L. Patmanidi, C.R. Hawes, R.D. Possee and L.A. King
A119 N-glycan dependent apical trafficking of a naturally N-glycosylated and GPI-anchored protein in polarised epithelial cells
P. Urquhart, S. Pang and N.M. Hooper
A120 The intracellular retention motif of the GABAB receptor 1 subunit interacts with COPI and 14-3-3z
C. Brock, J. Blahos and J.-P. Pin
A121 A search for the Weibel-Palade body fusion machinery reveals the expression of VAMP5 in human endothelial cells
L. Hewlett, S. Lorenz, T. Carter, V. O’Connor and M.J. Hannah
A122 Protein kinase D regulation of Kidins220 transport
L. Sánchez-Ruiloba, N. Cabrera-Poch, M. Rodríguez-Martínez and T. Iglesias
A123 Measuring the storage efficiency of von Willebrand factor in cultured endothelial cells and stably transfected cell lines
J.P. Giblin, L.J. Hewlett and M.J. Hannah

A201-A211 - Biochemical Society Annual Symposium: Lipid Rafts in Neuronal Function

Tuesday 20 July, 12:30-14:30
A201 Localisation and function of inositol 1,4,5-trisphosphate 3-kinase B in astrocytes
J.C.H. Yu, R.F. Irvine and M.J. Schell
A202 GABAB receptor constitutively associates with lipid rafts
A. Becher, A. Green, A. Wise, J.H. White and R.A.J. McIlhinney
A203 GABAA receptor subtypes localise to lipid rafts
A. Becher, F.A. Stephenson and R.A.J. McIlhinney
A204 Endocytosis in primary motor neuron cultures
K. Deinhardt and G. Schiavo
A205 Rituxan-induced relocalisation and oligomerisation of the CD20 into lipid rafts
E. Janas, R. Priest, J. Wilde, J. White and R. Malhotra
A206 The C-terminal domain of stomatin is proteolytically released from the membrane, revealing a novel function for this protein
K. Wilkinson, G.W. Stewart and N.M. Hooper
A207 Class II PI3-kinase C2a is essential for ATP-dependent priming of neurosecretory granule exocytosis
F.A. Meunier, F.T. Cooke, S.l. Osborne, G. Hammond, J. Domin, P.J. Parker and G. Schiavo
A208 Intracellular pathways involved in prion peptide trafficking in neurones
R. Wilson, J. Brewer, C. Bate and A. Williams
A209 The IgLON family of GPI-anchored cell adhesion molecules are located in lipid rafts and act as heterodimeric proteins
D. Moss, J. Reed and C. McNamee
A210 Effect of A-beta (25-35) peptide on sphingolipid pattern of rat cultured hippocampal neurons
E. Cazzaniga, E. Gatti, T. Mutoh and M. Masserini
A211 The role of phosphatidylinositol transfer proteins during axonal and dendritic growth
K.E. Cosker, A. Skippen, S. Cockroft and B.J. Eickholt

A301-A318 - Biochemical Society Annual Symposium: Cell Trafficking, Protein 'in'

Monday 19 July, 12:30-14:30
A301 Essential role for the phosphorylation of dynamin I in synaptic vesicle endocytosis
K.J. Smillie, V. Anggona, P.J. Robinson and M.A. Cousin
A302 BPGAP1 interaction with EEN/endophilin II downregulates mitogen-activated protein kinase signaling by promoting EGF-receptor mediated endocytosis
B.L. Lua and B.C. Low
A303 Amino acid signalling during starvation in autophagy
R. Koechl, X.W. Hu, E. Chan and S. Tooze
A304 Motors in endosomal sorting
O. Driskell, V. Allan and P. Woodman
A305 Identification and characterisation of candidate proteins involved in the trafficking of a novel lipid raft associated protein
C. Hamilton, V. Korolchuk, R. Rollason and G. Banting
A306 The regulation of EGF receptor traffic by RhoB
M. Wherlock, A. Gampel, C. Futter and H. Mellor
A307 Importin 7-mediated nuclear import of HIV-1 intracellular reverse transcription complexes.
L. Zaitseva, D. Görlich, I. Harrison, J.-M. Mingot and A. Fassati
A308 Cholesterol-dependent internalisation of the D6 chemokine receptor
V.A. Morrow and R.J.B. Nibbs
A309 Mutagenesis studies of the sodium channel b3 subunit: effects on trafficking and cell surface expression
E.J. Yu, A. Havard and A.P. Jackson
A310 Metal ion stimulated endocytosis of the cellular prion protein (PrPC) occurs by a clathrin-coated pit dependent mechanism
D.R. Taylor and N.M. Hooper
A311 Regulation of serotonin 5-HT2B receptor endocytosis by indirect interaction with the 5-HT1B receptor
M. Deraët, A. Janoshazi and L. Maroteaux
A312 Modulation of the 5-HT1B and 5-HT2B targeting and trafficking at the interface of the actin cytoskeleton
S. Günther, A. Janoshazi, M. Deraët and L. Maroteaux
A313 Endocytosis of dendriplexes is mediated by caveolin
M. Manunta, B. Nichols, P.H. Tan, P. Sagoo and A.J.T. George
A314 Cellular uptake of peptide-oligonucleotide conjugates: the effect of peptide composition and orientation
A. Arzumanov, J. Turner and M. Gait
A315 Sorting nexin-1 regulates mannose-6 phosphate receptor traffic
J. Carlton, M. Bujny and P. Cullen
A316 VEGFR1 trafficking in human endothelial cells
S. Mittar, G. Howell, M. Mohammed, L. Ewan, I. Zachary, J. Walker and S. Ponnambalam
A317 Entry of botulinum neurotoxin endopeptidase into cells: role of the binding domain
K.A. Foster, J.A. Chaddock, H.J. Moulsdale, Y. Hall and E. Kirby
A318 Multiple endocytic defects in cells expressing mutants of the small GTPase Rab21
J. Simpson, G. Griffiths, M. Wessling-Resnick and A.T. Jones
A319 Statins inhibit allergen-induced mast cell activation and lipid raft aggregation
R.A. Floto, M.A. Farrow, K. Smith and J.M. Allen

A401-A429 - Biochemical Society Annual Symposium: Lipid Biophysics (and Lipid-Protein) at the Molecular Level

Tuesday 20 July, 12:30-14:30
A401 Preliminary studies on the folding and reconstitution of a GPCR
A. Robson and P. Booth
A402 Optimization of thermal behavior of lipids from Yersinia pseudotuberculosis as a result of glucose additives to nutrition broth.
N.M. Sanina, S.I. Bakholdina, I.N. Krasikova, O.B. Popova and T.F. Solovéva
A403 Putative mechanism of transport of the long-chain saturated N-acylethanolamines in mammalian blood
M. Artamonov, O. Zhukov, O. Yakovenko and N.M. Gula
A404 Kinetic and secondary structural studies of rhodopsin regeneration from opsin binding to 11-cis-retinal
C. McKibbin, N. Farmer and P. Booth
A405 Poster Withdrawn
A406 Studies of the refolding behaviour of the small multidrug resistance proteins
K. Charalambous, P. Curnow and P. Booth
A407 Molecular mechanism of endophilin membrane binding and synaptojanin recruitment
J.L. Gallop and H.T. McMahon
A408 The role of membrane composition, structure and dynamics in the nuclear envelope assembly
M. Garnier, A. Grelard, G. Koster, S. Gschmeissner, A.D. Postle, E.J. Dufourc and B. Larijani
A409 Nuclear envelope assembly is promoted by phosphoinositide specific PLC with selective recruitment of phosphatidylinositol enriched membranes
R.D. Byrne, M. Garnier, G. Koster, M. Katan, A.D. Postle, D.L. Poccia, B. Larijani
A410 Biophysical studies into the membrane interactions of m-calpain domain V using neutron diffraction
S.R. Dennison, S. Dante, T. Hauss, F. Harris, K. Brandenburg and D.A. Phoenix
A411 CD analysis and neutron diffraction shows that deuteration affects the structure and membrane interactive potential of a bioactive protein segment
S. Dennison, S. Dante, T. Hauss, F. Harris, G. Siligardi and D. Phoenix
A412 Ceramide and fatty acid domains in the outer epidermis: spectroscopic studies of lipid dynamics and organization in model stratum corneum membranes
D.J. Moore
A413 Noradrenaline-stimulated phosphoinositide hydrolysis occurs in caveolae/rafts and involves phospholipase C-d1 in rat mesenteric small arteries
C.J. Clarke, V. Ohanian and J. Ohanian
A414 Aggregation and fibrillization of prions in lipid membranes
M.R. Hicks, J. Kazlauskaite and T.J.T. Pinheiro
A415 Expression of sn-1 DAG-lipases in the adult suggests a role in both cannabinoid and non-cannabinoid pathways.
P. Paul, C. Hobbs, G. Williams and P. Doherty
A416 Developmental expression of the first specific sn-1 DAG-lipases suggests a role in axonal growth and guidance
F. Howell, P. Paul, N. Thanos, C. Hobbs, E. Williams, G. Williams and P. Doherty
A417 An analysis of the phospholipid composition of immature and mature secretory granules by electrospray ionisation mass spectrometry
P. Sakya, G. Koster, S.A. Tooze, A.D. Postle and B. Larijani
A418 Fatty acid dietary preference of U937 cells
S. Hayavi, G. Duncan and G. Halbert
A419 Understanding interactions at the molecular level: specific or promiscuous? Rigid body or conformational change?
R. O’Brien
A420 Thioridazine, an antipsychotic that inhibits the activity of the synaptosomal plasma membraneCa21-ATPase but increases the rate of Ca21 accumulation
J. Palacios, M.R. Sepúlveda, A.G. Lee and A.M. Mata
A421 A genome-wide screen for mutants in sterol uptake and trafficking in yeast
S. Reiner, D. Micolod, G. Zellnig and R. Schneiter
A422 Regulation of lipid raft proteins by glimepiride- and insulin-induced glycosylphosphatidylinositol-specific phospholipase C in rat adipocytes
G.A. Müller, A. Schulz, S. Wied and W. Frick
A423 A new approach in investigating the role of phosphoinositides in membrane dynamics
N. Fili, V. Calleja, T. Postle, R. Woscholski, P. Parker and B. Larijani
A424 Investigation of lipid metabolism and processes of lipoperoxidation in old-aged patients with depressions
Y.P. Yelikova and P.I. Tsapok
A425 Effect of caffeine on oxidation susceptibility of human plasma low density lipoproteins
A. Krisko, M. Kveder and G. Pifat
A426 Kinetic studies on the folding of diacylglycerol kinase
A. Seddon, M. Lorch and P. Booth
A427 Conformational changes during pore-formation by equinatoxin, a potent sea anemone cytolysin
G. Anderluh, K. Kristan and P. Ma?cek
A428 Ceramide reduce cellular reactive oxygen species (ROS) through disruption of NADPH oxidase components within monocyte lipid rafts
Y. Luan and H. Griffiths
A429 Cytochrome c impaled
E. Kalanxhi, A.K. Smitheram, and C.J.A. Wallace

A501-A514 - Translocation Across the Endoplasmic Reticulum: Membrane and Protein Folding in the Lumen of the Endoplasmic Reticulum

Wednesday 21 July, 12:30-14:30
A501 Quality control of membrane proteins at the ER
S.G. Crawshaw, B. Martoglio and S. High
A502 Role of glutathione during the oxidative folding of tissue type plasminogen activator
S. Chakravarthi and N. Bulleid
A503 Identification of a pathway responsible for the reduction of oxidoreductases in the mammalian endoplasmic reticulum
C. Jessop and N. Bulleid
A504 Post-translational targeting of tail-anchored proteins to the ER
B.M. Abell and S. High
A505 The regulation of unfolded protein response by OASIS, a transmembrane bZIP transcription factor, in astrocytes
S. Kondo, T. Murakami, A. Wanaka, and K. Imaizumi
A506 The role of torsinA in protein quality control at the endoplasmic reticulum
A.C. Callan and E. Swanton
A507 The recognition of a dibasic degradation motif at the endoplasmic reticulum
A. Ray and S. High
A508 Physical and functional interdependence of Gpi17p with other GPI transamidase subunits in saccharomyces cerevisiae
Z. Yonghua, P. Fraering and A. Conzelmann
A509 Mutational analysis of the S. cerevisiae signal recognition particle RNA reveals a minimal core that interacts with non-essential variable regions
R.W. van Nues and J.D. Brown
A510 Characterisation of a novel thioredoxin domain protein in the endoplasmic reticulum
M. van Lith, N. Hartigan, J. Hatch and A. Benham
A511 Ero1Lbeta: not just another Ero1Lalpha
M. van Lith, S. Dias-Gunasekara, R. Kataky, G. Williams and A. Benham
A512 The biosynthesis of a polytopic membrane protein at the endoplasmic reticulum
N. Ismail and S. High
A513 A molecular analyisis of amyloid precursor protein biosynthesis
C.M. Wilson and S. High
A514 Membrane targeting and integration of a movement protein from a plant virus
A. Sauri, S. Saksena, A.E. Johnson and I. Mingarro

A601-A607 - Molecular Control of Immune Synapses

Wednesday 21 July, 12:30-14:30
A601 Isolation and characterization of CD38-containing detergent-insoluble membrane microdomains using non-ionic detergents
P. Muñoz, M.C. Navarro, E.J. Pavón, F. Malavasi, J. Sancho, and M. Zubiaur
A602 Lipid raft proteins have a random distribution during localised activation of the T cell receptor
O.O. Glebov and B.J. Nichols
A603 Contact-dependent intercellular communication between human natural killer cells and macrophages
S. Nedvetzki, S. Sowinski and D.M. Davis
A604 Analysis of proteins that bind to the itam motif of FcgRI or FcgRII receptors in U-937 cells induced to differentiate with vitamin-D3
I. Soto-Cruz and E. Ortega-Soto
A605 Lipid rafts facilitate the interaction of PECAM-1 with GPVI-FcRg complex in human platelets
F. Lee and R.W. Farndale
A606 Clustering of death receptors in lipid rafts initiates neutrophil spontaneous apoptosis
D. Scheel-Toellner, K. Wang, R. Craddock, P.R. Webb, L. Kaur Assi, M. Salmon and J.M. Lord
A607 Rapamycin-independent phosphorylation of PKCU at the C-terminal hydrophobic motif in T lymphocytes
M. Freeley, Y. Volkov, D. Kelleher and A. Long
A608 Innate retroviral immunity mediated by deoxycytidine deaminases
M.T. Liddament, W.L. Brown, A.J. Schumacher and R.S. Harris

A701-A703 - Cellular Motors

Thursday 22 July, 12:30-13:30
A701 Towards bridging the gap from molecular forces to the movement of organisms
B.G. Nielsen
A702 Centaurin-a1 interacts directly with a novel kinesin like motor protein
K. Venkateswarlu
A703 The role of cortical microtubules and F-actin in baculovirus trafficking
A.L. Patmanidi, J. Hoog, G.F. Rohrmann, R.D. Possee and L.A. King
A704 Intracellular trafficking of melanosomes in the retinal pigmented epithelium: mapping of interactions between Rab27a, Myrip and MyoVIIa
J.S. Ramalho, V.S. Lopes, C.E. Futter, P.C. Pereira and M.C. Seabra

A801-A802 - mRNA and Protein Synthesis Localisation

Thursday 22 July, 12:30-13:30
A801 Characterisation of the cis-acting element directing perinuclear localisation of the metallothionein-1 mRNA
H. Chabanon, D. Nury, I. Mickleburgh, B. Burtle and J. Hesketh
A802 Isolation and identification of a protein binding to the localisation element of metallothionein-1 mRNA
I. Mickleburgh, B. Burtle, D. Nury, H. Chabanon, Z. Chrzanowska-Lightowlers and J.E. Hesketh

Focus Topic: Signalling Outwards and Inwards

B101-B105 - PI 3-Kinase in the Immune System

Tuesday 20 July, 12:30-14:30
B101 In vivo characterization of centaurin-a2, an ARF GTPase activating protein that binds PI 3-kinase lipid products
K. Venkateswarlu, K.G. Brandom and H. Yun
B102 Essential role for p110d phosphoinositide 3-kinase in the allergic response
K. Ali, M. Thomas, W. Pearce, A. Bilancio, A. Gray, J. Giddings, E. Peskett, R. Fox, C. Walker,C. Sawyer, K. Okkenhaug, P. Finan and B. Vanhaesebroeck
B103 The role of phosphoinositide 3- kinases (PI3Ks) during haemopoietic differentiation
H.K. Bone and M.J. Welham
B104 The p110delta subunit of PI3K is required for the LPS response in mouse B cells
B.J. Hebeis, E. Vigorito and M. Turner
B105 The role of EPAC in a T lymphocyte cell line
S. Fuld and S. Yarwood
B106 Novel G protein-independent activation of phosphoinositide 3-kinase g (PI3Kg) via Ca21 and protein kinase C (PKC) regulates allergy
P. Küenzi, K. Björklöf, M. Laffargue, S. Tornay, G.W. Reuther, P. Finan, M. Thomas, E. Hirsch, M. Leitges and M.P. Wymann

B201-B206 - GSK 3b in Neuronal Function

Wednesday 21 July, 12:30-14:30
B201 Influence of lithium mineral waters on glial cell cultures
C. Munteanu, G. Zamfirescu, O. Zarnescu, D. Ciobotaru and A.S. Nica
B202 The MAP kinase pathway activates GSK3b stimulating the phosphorylation of MAP1B and axon growth
R.G. Goold and P.R. Gordon-Weeks
B203 Lithium resistance and prolyl oligopeptidase
K. McQuillan, J.W. Ryves and A.J. Harwood
B204 FRAT1, a substrate-specific regulator of GSK-3 activity, is a cellular substrate of protein kinase A
T. Hagen, D.A.E. Cross, A.A. Culbert, A. West, S. Frame, N. Morrice and A.D. Reith
B205 Characterisation of a novel splicing variant of GSK-3b
A. Wood-Kaczmar, K.L. Philpott and P.R. Gordon-Weeks
B206 Characterisation of the interaction of LANA with GSK-3 and its consequences for Wnt signalling
T. Hagen, F. Munoz, D. Hollyman and C. Boshoff

B301-B335 - Regulators of GPCR Specificity and GPCR Dimerization

Monday 19 July, 12:30-14:30
B301 Different mechanisms regulate internalization of P2Y1 and P2Y12 receptors
S.J. Mundell, A. Hardy, P.B. Conley and A.W. Poole
B302 Platelet purinergic P2Y1 and P2Y12 receptors desensitize by distinct kinase-dependent mechanisms
A. Hardy, P.B. Conley, A.W. Poole and S.J. Mundell
B303 The role of the third extracellular loop of the vasopressin V1a receptor; a G-protein-coupled receptor.
Z. Lawson and M. Wheatley
B304 Role of centaurin a1, an ARF6 GAP, in b2-adrenoceptor internalization
J.L. Lawrence, K.G. Brandom, E. Kelly and K. Venkateswarlu
B305 ATP and UTP stimulate inositol phosphate and cyclic AMP accumulation in rat neonatal cardiac fibroblasts
A. Talasila, R. Germack and J. Dickenson
B306 Two non-competitive antagonists are required per dimeric mGlu receptors to block receptor activity
V. Hlavackova, J. Kniazeff, C. Goudet, A. Zikova, D. Maurel, C. Vol, J. Trojanova, L. Prézeau,J.-P. Pin and J. Blahos
B307 Is the P2Y14 receptor functionally expressed in SH-SY5Y and U373 MG cells?
M. Scrivens, M.G. Darlison and J.M. Dickenson
B308 Functional characterisation of P2Y receptors in SK-MES cells: predominance of pyrimidine nucleotide receptors
R.C. Allsopp and T.E. Webb
B309 Identification of protein interaction partners for EPAC
M. Gupta and S.J. Yarwood
B310 Characterisation of breast cancer cells for neuropeptide Y binding sites
C.M. Deckert, A. Böttner, N. Koglin and A.G. Beck-Sickinger
B311 Expression and functional analysis of the chemokine receptor CCX-CKR
I. Comerford and R.J.B. Nibbs
B312 Involvement of a cytoplasmic-tail serine cluster in urotensin II receptor internalization
C. Proulx, M. Simaan, E. Escher, S. Laporte, G. Guillemette and R. Leduc
B313 Analysis of NPY receptor dimerization in living cells by fluorescence resonance energy transfer (FRET)
I. Böhme, R. Rennert, M.C. Dinger, K. Mörl and A.G. Beck-Sickinger
B314 Investigation of the effect of nitric oxide on signalling by the a and b isoforms of the human thromboxane A2 receptor
H.M. Reid and B.T. Kinsella
B315 G-protein signalling: towards a better understanding using fluorescence resonance energy transfer?
M. Nobles, A. Benians and A. Tinker
B316 Evidence to support a spectrum of receptor active states
N. Strudwick, N. Evans, N. Bhogal, F. Blaney and J. Findlay
B317 Arachidonic acid inhibits store-operated Ca21 channels (measured using patch-clamp recording) in rat liver H4-IIE cells
G. Rychkov, T. Litjens, M. Roberts and G.J. Barritt
B318 In vivo DNase I-mediated footprinting analysis along the human bradykinin B1 receptor (BDKRB1) gene promoter: evidence for cell-specific regulation
M. Angers, R. Drouin, M. Bachvarova, I. Paradis, M. Hiromura, A. Usheva and D. Bachvarov
B319 Desensitization of M1 muscarinic acetylcholine receptor (mAChR) signalling by GRK2 in hippocampal neurones is phosphorylation-dependent
J.M. Willets, S.R. Nahorski and R.A.J. Challiss
B320 The use of GST fusion proteins to identify hPAC1R interacting proteins and their sites of interaction
E. Ronaldson, P. Shaw, M.S. Johnson, R. Mitchell and E.M. Lutz
B321 Modulation of adenylyl cyclase activity and [3H]forskolin binding in young and adult rat brain cortex
J. Stöhr, L. Bourova, V. Rudajev, J. Novotny and P. Svoboda
B322 Profiling of M3 and a1B receptor-mediated phospholipase C activation using single-cell ‘biosensors’
P.J. Bartlett, K.W. Young, S.R. Nahorski and R.A.J. Challiss
B323 Pharmacological characterisation of the AMY1(a) receptor
D.L. Hay, G. Christopoulos, A. Christopoulos and P.M. Sexton
B324 Allosteric modulation of adenosine A1 receptors by SCH-202676
L.T. May, P.M. Sexton and A. Christopoulos
B325 Comparison of muscarinic acetylcholine receptor- and bradykinin receptor-mediated phosphorylation of the transcription factor CREB
E. Rosethorne, S.R. Nahorski and R.A.J. Challiss
B326 The effect on CGRP-affinity and signalling of mutations to proline residues within the transmembrane regions of human calcitonin receptor-like receptor (CL)
A.C. Conner, D.L. Hay, J. Simms, S.G. Howitt, M. Wheatley, D.M. Smith and D.R. Poyner
B327 His7.36(305) of the gonadotropin-releasing hormone (GnRH) receptor determines recognition of Trp3 of GnRH
N. Mayevu, Z. Lu, R. Roeske, R.P. Millar, A. Katz and C.A. Flanagan
B328 Identification of surrogate peptide ligands for rat mas protooncogene using phage-displayed random peptide library
R.K. Bikkavilli and W.-T. Cheung
B329 Identification and characterisation of Group II mGluR-interacting proteins
K. Lidwell, B. Pilkington, O. El Far, H. Betz and V. O’Connor
B330 Generation of amino-terminal epitope tagged PAC1 receptors
P.E. Shaw, E. Ronaldson, M.S. Johnson, R. Mitchell and E.M. Lutz
B331 Occupancy of the D2short dopamine receptor is affected by sodium ions and varies with the membrane batch
M. Vivo and P.G. Strange
B332 The use of explanted retinas to study GPCR-linked proteins and treatment of hereditary retinal diseases
Y. Yu, S. Hayavi, F. Roberts, G.W. Halbert, J.N.A. Tettey and C.A. Converse
B333 Re-challenge with neuromedin U contracts isolated rat colon but does not mediate Ca21 responses in colonic smooth-muscle cells
P.J. Brighton, A. Wise, N.B. Dass and G.B. Willars
B334 Lack of effect of receptor phosphorylation on the inhibitory actions of RGS2 and RGS3
S.C. Tovey, A. Karakoula and G.B. Willars
B335 Sphingosine 1-phosphate regulates myogenic differentiation. A major role for S1P2 receptor
C. Donati, E. Meacci, F. Nuti, L. Becciolini, M. Farnararo and P. Bruni
B336 The heptaheptical domain of GABAB2 is directly activated by CGP7930, a positive allosteric modulator of the GABAB receptor
V. Binet, C. Brajon, L. Le Corre, F. Acher, J.-P. Pin and L. Prézeau
B337 Differences in the mechanism of internalization of LPA2 and LPA3 receptors
J.L. Lawrence, E. Kelly and K. Venkateswarlu

B401-B408 - Complexity of Adhesion Contacts

Thursday 22 July, 12:30-13:30
B401 Protein 4.1R binding death receptors of the erythrocyte membrane
Z.E. Lee, D.J. Head, J. Poole, L. Kennedy and N.D. Avent
B402 Functional analysis of the cytoskeletal proteins talin1 and talin2
Y. El Jai, S.J. Monkley, C.A. Pritchard and D.R. Critchley
B403 Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure
S.A. van de Pavert, A. Kantardzhieva, A. Malysheva, J. Meuleman, I. Versteeg, C. Levelt, J. Klooster,S. Geiger, M.W. Seeliger, P. Rashbass, A. Le Bivic and J. Wijnholds
B404 Engagement of syndecan-4 is essential for adhesion-stimulated Rac1 activation and focal complex formation
M.D. Bass, Z. Mostafavi-Pour and M.J. Humphries
B405 Vinculin involvement in lipid regulation of adhesion site turnover
I. Chandrasekar, M.R. Holt, T.E.B. Stradal, B.M. Jockusch and W.H. Ziegler
B406 Effect of hypoxia-reoxygenation on gut epithelium: is 4-hydroxynonenal capable of inducing barrier dysfunction?
C. Hoare and G. Warhurst
B407 Use of 2D gel electrophoresis to investigate changes in tyrosine phosphorylation during osteoblast adhesion
E.A. Elton, C. Scotchford, D. Grant and P. Jones
B408 The molecular mechanism of cadherin adhesion
O.J. Harrison, E.M. Corps and P.J. Kilshaw

B501-B502 - b-Catenin/Wnt Signalling

Wednesday 21 July, 12:30-14:30
B501 The role and regulation of wisps during chondrogenesis
K. Balakrishnan and P. Francis-West
B502 Plakoglobin expression and localization in zebrafish embryo development
E.D. Martin and M. Grealy

B601-B605 - Insulin Signalling

Thursday 22 July, 12:30-13:30
B601 Isoproterenol and insulin signalling in primary adipocytes
C.A. Hudson and S.K. Moule
B602 Phospholipid imbalance through addition of phosphatidylcholine triggers IGF-1-like-responses linked to glucose metabolism in C2C12 myoblast cells
C. Rauch and P.T. Loughna
B603 Activation of NFkB mediates the suppression of glucose-6-phosphatase gene expression by TNF, but not by insulin
R. Grempler, A. Kienitz, T. Werner, M. Meyer, A. Barthel, F. Ailett, C. Sutherland, R. Waltherand D. Schmoll
B604 A new LMNA mutation associated with familial partial lipodystrophy
I. McFarlane, D. Savage, D. Halsall, M. Soos and S. O’Rahilly
B605 Structural studies into fibroblast growth factors.
L.E. Adam, N.J. Harmer and T.L. Blundell

B701-B710 - Integrins, Structure and Function

Thursday 22 July, 12:30-13:30
B701 Structural studies of the interaction between the cytoskeletal proteins talin and vinculin
A.R. Gingras, E. Papagrigoriou, I. Barsukov, D.R. Critchley and J. Emsley
B702 Structure of the integrin a2b1 binding collagen peptide
J. Emsley, C.G. Knight, R.W. Farndale and M.J. Barnes
B703 Growth factor regulation of integrin recycling in primary cultured human endothelial cells
M.C. Jones, P.T. Caswell, D.P. White and J.C. Norman
B704 Different signalling pathways are employed by alpha-4 beta-1(a4b1) and alpha-5 beta-1(a5b1) integrins during focal adhesion formation and migration
Z. Mostafavi-Pour, N.O. Deakin, M.D. Bass and M.J. Humphries
B705 CD14 is a novel a4b1 integrin ligand
J.D. Humphries and M.J. Humphries
B706 Visualising b1 integrin interactions
A.J. Messent, M. Parsons and M.J. Humphries
B707 Collagen binding by a2b1 is regulated by cation-binding sites in both integrin subunits
D. Valdramidou, T. Benkert, A.P. Mould and M.J. Humphries
B708 Beta 1 integrin and HERG1 potassium channels form a macromolecular complex involved in cell signalling
A. Cherubini, G. Hofmann, S. Pillozzi, L. Guasti, O. Crociani, E. Cilia, M. Balzi, R. Wymore, P. Defilippi,E. Wanke, A. Becchetti and A. Arcangeli
B709 Fishing for integrins in Danio rerio
A.P. Mould, J.A. Hamilton, A. Hurlestone and M.J. Humphries
B710 Structure of a 14kDa domain from the cytoskeletal protein talin and its interaction with vinculin
I.J. Fillingham, I.G. Barsukov, D.R. Critchley and G.C. Roberts
B711 PKD1/PKCm promotes avb3 integrin recycling and delivery to nascent adhesions
A.J. Woods, D.P. White, P.T. Caswell and J.C. Norman

B801-B830 - Oncogenesis

Monday 19 July, 12:30-14:30
B801 Poster Withdrawn
B802 Poster Withdrawn
B803 Comparative functional analysis of the native and PTI-1-like form of eEF1A
A.P. Pogribna, B.S. Negrutskii and A.V. El’skaya
B804 TEL/ETV6 is important for angiogenesis, gut development and neuronal cell survival
S.M.N. Onnebo and A.C. Ward
B805 Androgen receptor and endometrial cancer risk
M. McGrath, S.E. Hankinson, P. Kraft, D.J. Hunter and I. De Vivo
B806 Regulation of the DNA binding ability of p53 protein by phosphorylation and by monoclonal antibodies
V. Brazda, E. Jagelska, P. Pecinka and E. Palecek
B807 Enhancement of p53 sequence-specific binding by DNA supercoiling
E. Jagelska, V. Brazda, P. Pecinka, L. Karlovska and E. Palecek
B808 Characterisation of human RhoBTB2/DBC2, a novel Rho GTPase
L.-A. Skelton and H. Mellor
B809 The association of connexin43, hDlg and HPV-16 E6 in cervical carcinogenesis
S. Peng, M.B. Hodgins, M. Edward, S. Roberts and S.V. Graham
B810 The integrity of cholesterol-enriched micro-domains is essential for the constitutive high activity of protein kinase B in tumor cells
S. Elhyany, E. Assa-Kunik, S. Segal and D. Fishman
B811 Runx 1 - A role in early oncogenesis?
S. Wotton, A. Kilbey, K. Blyth, L. Hanlon, A. Jenkins, J.C. Neil and E.R. Cameron
B812 Tyrphostin AG-490 inhibits the phosphorylation of activated JAK3 kinase in the transformed cervical cell lines CALO and INBL
A. Valle, A. García, X. Moreno, R. Santiago, R. Rangel, J. Mendoza, B. Weiss and I. Soto
B813 Poster Withdrawn
B814 What is the leukocyte protein, L-plastin, doing in colon cancer cells?
E. Foran, P. McWilliam, D.T. Croke and A.C. Long
B815 Immunoporation: a method for enhancing chemotherapy
F. Gao, L. Bildirici and D. Rickwood
B816 Signaling pathways of the MEN2B mutant of RET
C.H. Chan, H.K. Lee and S.Y. Chan
B817 Isoform of v-src oncoprotein isolated from low metastatic cell line is unable to activateN-acetylglucosaminyltransferase V
N. Isachenko and V. Aushev
B818 MUC1 is a novel partner for the integral lipid raft protein MAL2 in breast carcinoma cells
S. Fanayan, M. Shehata, M. McGuckin and J.A. Byrne
B819 Disparity between DNA methylation status of peripheral blood leucocytes and rectal mucosal cells
Y.M. Duckworth, E.A. Williams, M. Welfare, H.J. Powers and J.C. Mathers
B820 Redox regulation of PI 3-kinase signalling via inactivation of PTEN
N.R. Leslie, Y.E. Lindsay, S.H. Ross, D. Bennett and C.P. Downes
B821 An investigation into the role of Bcl-2 in neuroendocrine differentiation
I.S. Cadden, B.T. Johnston, Y. Tsujimoto, Y. Eguchi, D.R. McCance, J.E.S. Ardill and A. McGinty
B822 Evaluation of Cox-2 as a biomarker in mid-gut carcinoid tumours
I.S. Cadden, B.T. Johnston, G.B. Turner, D.R. McCance, J.E.S. Ardill and A. McGinty
B823 Supercoil-selective DNA binding of tumor suppressor protein p53
M. Fojta, H. Pivonkova, K. Nemcova, M. Brazdova, J. Palecek, B. Vojtesek and E. Palecek
B824 Recognition of DNA modified with platinum complexes by protein p53
H. Pivonkova, M. Brazdova, B. Vojtesek, J. Kasparkova, N. Farrell, V. Brabec and M. Fojta
B825 Carbohydrates in signalling through activating receptors of killer lymphocytes: from functional genomics and proteomics to glycomimetics and tumour therapies
K. Bezouska, P. Man, P. Pompach, O. Plihal, L. Mihok and J. Pavlicek
B826 Poster Withdrawn
B827 Signalling via vascular endothelial growth factor receptor-2 utilises the ShcA-related adapter protein, Sck/ShcB
S.K. Harris and S.A. Prigent
B828 A novel mechanism involving androgen control of PKC expression in prostate cancer cells: implications for apoptosis
M.V. Gavrielides, A. Gonzalez-Guerrico, S. Nakagawa, M. Nakagawa, L. Sanchez-Ruilobaand M.G. Kazanietz
B829 Oestrogen receptor-a, Efp, 14-3-3s and methylation studies in human mammary carcinomas
H.M. Welch, M. Harrison, F. Cooke, A. McCann, A. McGoldrick, E. Gallagher, O.M. McCormack,W.Y. Chung, M.J. Kerin and P.A. Dervan
B830 PKC-independent diacylglycerol signalling: essential role for the b2-chimaerin C1 domain in targeting its association with the Rac GTPase
H. Wang, C. Yang, F. Coluccio Leskow, J.L. Oliva-Martinez, E. Griner, J. Wang, B. Canagarajah,J.H. Hurley, and M.G. Kazanietz
B831 A novel three stage in vitro pre-screen test system for anti-tumour drugs
A. Reith, M. Edward, D.A. Greenhalgh and M.B. Hodgins

Focus Topics: Structure Related to Function: Molecules and Cells

C101-C118 - Signalling Lipid-Protein Interactions (Structural)

Wednesday 21 July, 12:30-14:30
C101 A mechanosensitive ion channel in its membrane environment
A.M. Powl and A.G. Lee
C102 Regulation of phosphatidylinositol 5-phosphate levels in cells
H.F. Roberts, R.F. Irvine and K.A. Hinchliffe
C103 Targets and regulation of GAP1 proteins
F. Bhatti, K.A. Hinchliffe and R.F. Irvine
C104 Investigation of b Centaurin Arf-GAPs in melanoma cells.
R. Martin and T. Jackson
C105 Inositol lipid binding properties of native and mutant centaurin-a1 PH domains
K.G. Brandom and K. Venkateswarlu
C106 Roles of caleosins in plants
M.R. Partridge and D.J. Murphy
C107 The regulation of FAB1, a phosphatidylinositol 3-phosphate 5-kinase found in Saccharomyces cerevisiae
J.P. Phelan and F.T. Cooke
C108 Prostaglandin (PG)E2- and PGF2a-induced cross-desensitization of the alpha (a) and beta (b) isoforms of the human thromboxane A2 receptor
L.P. Kelley-Hickie and B.T. Kinsella
C109 Dietary ganglioside alters the composition of gangliosides in specific locations in the enterocyte
E.J. Park, M. Suh and M.T. Clandinin
C110 Effect of antioxidants on the cytosolic phospholipase A2 activity in HUVEC
H. Khaza’ai and M.S.A. Mutalib
C111 Purification and characterization of a cPKC like kinase, associated with low temperature induced phosphorylation changes in Brasssica juncea seedlings
R. Deswal, G.K. Chowdhary and S.K. Sopory
C112 In vitro inhibition effects of some new sulfonamide inhibitors on human carbonic anhydrase I and II
Ã-. Ã-zensoy, Ãœ. Çakir, H.I. U?gras, S. Sinan and O. Arslan
C113 R-(1)-win-55,212-2 inhibits nitric oxide and prostaglandin E2 production and cartilage degradation
E.C. Mbvundula, R.A.D. Bunning and K.D. Rainsford
C114 Investigation of the function of the d4 family of zinc finger proteins during development
J. Wanless, I. Merstalov, D. Kulikova, N. Ninkina and V. Buchman
C115 Lipid rafts aggregation and signalling by listeriolysin O
N.O. Gekara, T. Jacobs, T. Chackraborty and S. Weiss
C116 HAMLET, a protein folding variant inducing apoptosis in tumor cells
J. Pettersson, A. Mossberg, S. Linse and C. Svanborg
C117 Characterising the interaction of fragments derived from Bcl-2 proteins with membranes
A.J. García-Sáez, M.D. Serra, G. Menestrina, M. Coraiola, E. Pérez-Payà, I. Mingarro and J. Salgado
C118 a-Diacylglycerol kinase is a potential target for angiogenesis and metastasis control
G.L. Baldanzi, S. Mitola, S. Cutrupi, F. Chianale, W. van Blitterswijk, F. Bussolino and A. Graziani

C201-C202 - Ubiquitination

Tuesday 20 July, 12:30-14:30
C201 Structural and functional studies of mutations affecting the UBA domain of SQSTM1 (p62) which cause Paget’s disease of bone
R. Layfield, B. Ciani, S.H. Ralston, L.J. Hocking, P.W. Sheppard, M.S. Searle and J.R. Cavey
C202 Structural studies on USP7/HAUSP interactions with EBNA1 and p53
Y. Sheng, V. Saridakis, M. Holowaty, A. Edwards, C. Arrowsmith and L. Frappier

C301-C322 - Structure of Membrane Proteins

Monday 19 July, 12:30-14:30
C301 The in vitro studies of schistosomicidal potency of Nigella sativa seeds against Schistosoma mansoni different stages
A.M. Mohamed, N.S. Metwally and S.S. Mahmoud
C302 Active and inactive conformations of the epidermal growth factor receptor
S. Li and K.M. Ferguson
C303 The role of the 2nd extracellular loop in the functioning of the V1a vasopressin receptor
M. Conner, A. Baker, A. Conner, S. Hawtin, Z. Lawson, K. Lowry, J. Simms, D. Woottenand M. Wheatley
C304 Structural studies of recombinant human P-glycoprotein
A. Bukar Kamis, M.F. Rosenberg, J. Storm, R. Callaghan and R.C. Ford
C305 Poster Withdrawn
C306 Three dimensional structure of type 1 inositol 1,4,5-trisphosphate (IP3) receptor bound to IP3
P.L. Fernando, E. Taylor, E.P. Morris, P.C.A. da Fonseca, A. Riley, B.V.L. Potter and C.W. Taylor
C307 Structural and functional studies of peptides involved in regulation of Ca21 transport
J.C. Clayton, E. Hughes and D.A. Middleton
C308 Purification, crystallisation and structural analysis of CFTR
M.F. Rosenberg, A. Bukar Kamis, L.A. Aleksandrov, R.C. Ford and J.R. Riordan
C309 What is the functional role of non-membrane associated ABC transporter nucleotide binding domains?
I.D. Kerr
C310 NMR structural studies of lung surfactant protein B peptides
V. Booth, A.J. Waring, F.J. Walther, K.M.W. Keough
C311 Towards crystallization of a mal-E-M1 muscarinic receptor fusion protein
E.C. Hulme and C.A.M. Curtis
C312 The expression of TRPC7 in pancreatic cells and 3T3-L1 adipocytes
K.L. Ralphs, P. Chen, D. Tosh and A.J. Wolstenholme
C313 Fluorescent labelling of individual residues allows clarification of the refolding pathway of bacteriorhodopsin
E. Compton, N. Farmer and P. Booth
C314 Homo-oligomerisation of leukotriene C4 synthase detected by bioluminescence resonance energy transfer (BRET)
J. Svartz, R. Blomgran, S. Hammarström and M. Söderström
C315 A novel gene homologue of the angiotensin converting enzyme family.
J. Elliott, A. Phelan, J. Lanfear, S. Ballard, E. Karran, A. Turner and N. Hooper
C316 The role of A60 of BCG’s cell wall in diagnosis of tuberculosis
F. Fallah, M. Fallah, G. Eslami, H. Goudarzi, B. Kazemi and F. Doostdar
C317 Dual polarisation interferometry studies of transglutaminase and chloride ion channel protein CLIC-1
S. Carrington, S. Lismaa, S. Holman, J. Popplewell and G. Ronan
C318 The electrolyte and membrane peroxidation status of sickle red cells
R.A. Adisa, J.A. Gbadebo and O.O. Olorunsogo
C319 Molecular structure and processing of the IgA protease, a type V autotransporter
H.K. Parsons, S.P. Thomson, T.J. Stillman, S. Vitovski, P.J. Artymiuk and J.R. Sayers
C320 Effect of muscular dystrophy on cholinesterases of mouse thymus
S. Nieto-Cerón, L. Sánchez del Campo, E. Muñoz-Delgado, C.J. Vidal and F.J. Campoy
C321 Levels of eNT mRNA, immunolabeled eNT protein and eNT activity in mouse tissues
J.C. Morote-García, F.J. Campoy, C.J. Vidal and E. Muñoz-Delgado
C322 Acetylcholinesterase and butyrylcholinesterase in control and neoplastic human colorectal specimens
F. Montenegro, S. Nieto-Cerón, F. Ruiz-Espejo, M. Páez de la Cadena, J. Rodríguez-Berrocaland C.J. Vidal

C401-C407 - Observing Single Molecules

Monday 19 July, 12:30-14:30
C401 Evaluation of an in vitro model system for neurite outgrowth and synaptic plasticity
R. Eva and G. Banting
C402 Visualising DNA polymerisation at the single molecule level using confocal and TIRF microscopy
R.D. Perrins, R.A. Meldrum, C.W. Wharton, M.L. Martin-Fernandez , M.J. Tobin and C.R. Bagshaw
C403 Single protein molecular dynamics determined with ultra-high precision
Y.C. Sasaki
C404 Covalent labeling of fusion proteins in living cells
S. Gendreizig and K. Johnsson
C405 Structural changes in supercoiled DNA induced by its interaction with PARP-1
S. Chasovskikh, A. Dimtchev and A. Dritschilo
C406 Structural dynamics of mononucleosomes studied with single pair FRET and fluorescence correlation spectroscopy (FCS)
A. Gansen, F. Hauger, K. Toth and J. Langowski
C407 Probing conformational dynamics in signalling EGF receptors with multidimensional single molecule fluorescence microscopy
S.E.D. Webb and M.L. Martin-Fernandez

C501-C513 - Proteomics of Macromolecular Complexes

Thursday 22 July, 12:30-13:30
C501 Compensatory energetic mechanisms mediating the assembly of signalling complexes between interleukin-2 and its a, b and gc receptors
M. Rickert, M.J. Boulanger, N. Goriatcheva and K.C. Garcia
C502 Role of WT1 (Wilms tumour suppressor gene) in podocyte differentiation and disease
R. Viney, A. Morrison, I. Witherden, M. Saleem and M. Ladomery
C503 The mitochondrial protein import machineries - organization, dynamics and cooperation
A. Chacinska, P. Rehling, N. Wiedemann, C. Meisinger and N. Pfanner
C504 Protein-protein interactions in the human pyruvate dehydrogenase complex
M. Smolle, O. Byron and J.G. Lindsay
C505 Isoprotein-specific interactions of apolipoprotein E with tissue plasminogen activator
S. Carrington, S. Biehle, J. Popplewell and J. Clark
C506 Evaluation of the heterozygous reeler mouse as a suitable animal model for schizophrenia
E.J. Armstrong, G.F. O’Meara, J. Groves, R.P. Heavens, I.L. Schurov, D.S. Reynolds and N.J. Brandon
C507 Identification of proteins associated with lipid rafts of Jurkat T-cell line by mass spectrometry
P. Pompach, P. Man, P. Novak, A. Fiserova, V. Havlicek and K. Bezouska
C508 A proteomic investigation of the role of WT-1 in disease
A.A. Morrison, R. Viney and M. Ladomery
C509 Proteomic analysis of Cdk5: identification of its novel negative regulator
A.C.-B. Lim and R. Qi
C510 Src-mediated activation of diacylglycerol kinase-zeta by the GnRH receptor
L. Davidson, A.J. Pawson, R.P. Millar and S. Maudsley
C511 Proteomic analysis of micro-dissected neurons from Huntington disease brains
D.P. McGowan, R.L.M. Faull, P.C. Emson and M. Starkey
C512 The shikimate pathway in Toxoplasma gondii: an ancient eukaryotic innovation
S.A. Campbell, T.A. Richards, E.J. Mui, B.U. Samuel, J.R. Coggins, R. McLeod and C.W. Roberts
C513 Biochemical exploration of the FGF receptor complex with heparin
N.J. Harmer, L.E. Adam, L. Pellegrini and T.L. Blundell

C601-C607 - Cell Trafficking at the Structural (Atomic) Level

Tuesday 20 July, 12:30-14:30
C601 Targeting of inositol 1,4,5-trisphosphate receptors to the endoplasmic reticulum by multiple signals within their transmembrane domains
A.K.T. Parker, F.V. Gergely and C.W. Taylor
C602 Early events in NPC formation
H.S. Sanderson and T.D. Allen
C603 Structural features of the LDL receptor facilitating ligand release at low pH
N. Beglova, H. Jeon, C. Fisher and S.C. Blacklow
C604 Structural characterization of the interactions between the AAA ATPase p97 and its adaptor protein p47
I. Dreveny, H. Kondo, K. Uchiyama, F. Beuron, A. Shaw, X. Zhang and P.S. Freemont
C605 Preliminary structure function studies of p97 AAA ATPase
L. Briggs, G. Baldwin, X. Zhang and P. Freemont
C606 Preliminary characterisation studies of the p97, Ufd1-Npl4 and ubiquitin complexes
V. Pye, F. Beuron, C. McKeown, C. Keetch, C. Robinson, H. Meyer, X. Zhang and P. Freemont
C607 Studying interactions between ligands and membrane proteins by solid state NMR
M.P. Boland and D.A. Middleton

C701-C705 - Ribosomes and Chaperones (Structure)

Thursday 22 July, 12:30-13:30
C701 Gene trap modification of Nol1 (nucleolar protein 1) - a tool for analysis of Nol1 expression and function
D. Mitrecic, T. Malnar, M. Curlin, L. Kostovic-Knezevic and S. Gajovic
C702 Chaperone-like activity of mammalian elongation factor eEF1A
T.A. Lukash, H.V. Turkivska, B.S. Negrutskii and A.V. El’skaya
C703 The role of chaperone donor peptide in Yersinia pestis capsular antigen polymerisation
L.J. Fooks and S. MacIntyre
C704 Novel conformations of initiating yeast 40S ribosomal subunits
R.J. Gilbert, T. von der Haar, Y.E. Gordiyenko, D.I. Stuart and J.E.G. McCarthy
C705 Poster Withdrawn

C801-C804 - Dynamic Imaging Techniques

Monday 19 July, 12:30-14:30
C801 Chemokines and neuroinflammation modelled in vitro
A.G. MacLean, D. Bieniemy and A.A. Lackner
C802 IT challenges of cellular imaging technologies in drug discovery: an image management solution architecture
V. Vutukuru
C803 Observation of a fluorescently labelled virus on its infectious entry pathway into the cell using fluorescence correlation spectroscopy
S. Bernacchi, G. Mueller, J. Langowski and W. Waldeck
C804 Diffusion of eqFP611 molecules in living interphase HeLa cell nuclei studied with FCS
N. Dross and J. Langowski

C901-C908 - Glycosylation

Thursday 22 July, 12:30-13:30
C901 THe inositol 5-phosphatase SKIP binds ARL6 interacting protein AIP1
R. Gurung and C.A. Mitchell
C902 Structural basis of glycogen synthesis
A. Buschiazzo, M.E. Guerin, J.E. Ugalde, W. Shepard, R.A. Ugalde and P.M. Alzari
C903 Glycosidase activity in Peyer’s patch model co-cultures and a mucin-secreting cell line
J.A. Irwin, J.P. Ryan, S. Cochrane, S. Keely, S.D. Carrington and A.W. Baird
C904 Regulation of the activity and range of signalling of Nodal
J.A. Le Good, A.J. Giraldez, K. Joubin, N. Ben Haim, S. Beck, A. Schier and D.B. Constam
C905 Glycosylation of PrP and the species barrier in transmissible spongiform encephalopathies
F. Wiseman, E. Cancellotti, N. Tuzi, H. Baybutt, L. Aitchison, J. Ironside and J. Manson
C906 Dolichol-phosphate-mannose synthase from Trypanosoma brucei
J.A. Nunes and T.K. Smith
C907 N-glycosylated catalytic unit meets O-glycosylated propeptide: complex protein architecture in fungal hexosaminidase
O. Plihal, J. Sklenar, P. Man, P. Pompach and K. Bezouska
C908 The N-glycan glucosidase system in Trypanosoma brucei
D. Jones, A. Mehlert and M.A.J. Ferguson
C909 Fucosylation and the neural anti-horseradish peroxidase epitopes of Drosophila melanogaster and Caenorhabditis elegans
G. Fabini, D. Rendi´c, K. Paschinger and I.B.H. Wilson

Focus Topic: Genes: Regulation, Processing and Interference

D101-D124 - Chromatin and Gene Regulation

Thursday 22 July, 12:30-13:30
D101 Complementary enzyme-coenzyme mutagenesis: labelling the substrates of a transcriptional acetylase
L. Willetts, P. Gillece, N.R. Thomas and E. Stylianou
D102 Mutational analysis of the dimerisation interfaces of the androgen and glucocorticoid receptor DNA-binding domains
G. Verrijdt, A. Peeters, K. Schauwaers and F. Claessens
D103 Genes with cell type specific DNA methylation patterns in normal tissue exhibit novel patterns of histone modifications
G. Strathdee, A. Sim and R. Brown
D104 Identifying interactions of the transcription factor REST throughout the genome
L. Ooi, I.C. Wood, A.W. Bruce and N.J. Buckley
D105 Aberrant methylation at pro-apoptotic genes in ovarian cancer is associated with clinical outcome
J. Teodoridis, G. Gifford, J. Curto-Garcia, J. Paul, P. Vasey, G. Strathdee and R. Brown
D106 REST targets in neural stem cells and adult neurons
D.J. Greenway, A.H. Handyside and N.J. Buckley
D107 REST-mediated transcriptional repression in neural cells
R. Johnson, A. Bruce, L. Ooi and N.J. Buckley
D108 Differential effect of acetylation on IL-1 induced gene transcription
S. Linstead and E. Stylianou
D109 UBF binding site arrays form pseudo-NORs and sequester the RNA Pol I transcription machinery
C. Mais, J.E. Wright, S.L. Raggett and B. McStay
D110 Gene microarray analysis of plaque, peri-plaque and normally-appearing white matter (NAWM) brain tissue from multiple sclerosis patients
M. Padden, S. McQuaid and B. Brankin
D111 Prolyl oligopeptidase and regulation of inositol phosphates
M. Keim, R.S.B. Williams and A.J. Harwood
D112 Transfection of cells by immunoporation using silica beads
L. Bildirici, F. Gao and D. Rickwood
D113 Epigenetic approaches to cancer therapy
J.A. Plumb, N. Fernie, P.W. Finn and R. Brown
D114 cAMP-dependent agents activate CYP51 gene transcription independently of the cellular lipid level
M. Fink, N. Tansek and D. Rozman
D115 Chromosomal proteins HMGN3a and HMGN3b regulate the expression of glycine transporter 1
K.L. West, M. Castellini, Y. Ito, M. Duncan and M. Bustin
D116 Regulation of the archaeal DNA-binding protein, Alba, by post-translational modification
D.T. Gilliland, M. White and G. Taylor
D117 The recruitment of histone modifications necessary for the barrier activity of the HS4 insulator
A.G. West, S. Huang, M. Gaszner and G. Felsenfeld
D118 Functional analysis of the N terminus of the general transcription factor (GTF) TFIIB
L.M. Elsby and S.G.E. Roberts
D119 Characterisation of SWI/SNF dependent chromatin disruption at the yeast HO promoter
T. Gkikopoulos, K.M. Havas and T. Owen-Hughes
D120 Complex regulation and nuclear localisation of JRK protein
R. Waldron and T. Moore
D121 Effect of histone post-translational modifications on ATP-dependent chromatin remodelling activities
H. Ferreira, A. Flaus, C. Stockdale and T. Owen-Hughes
D122 Characterisation of yeast ISWI complexes
C. Stockdale, H. Ferreira and T. Owen-Hughes
 
D123 poster withdrawn
 
D124 Generation of non-canonical nucleosomes as a result of nucleosome repositioning
M. Engeholm, A. Flaus, M. Bruno and T. Owen-Hughes

D201-D229 - Transcription Regulation in Development and Signalling

Wednesday 21 July, 12:30-14:30
D201 The role of post-translational hydroxylation in eukaryotic oxygen sensing
D.E. Lancaster, L.A. McNeill, M.A. McDonough, R.T. Aplin, K.S. Hewitson, C.W. Pugh, P.J. Ratcliffeand C.J. Schofield
D202 Fos-related antigen 1 (Fra-1) in the rat amygdala might be involved in the acquisition and consolidation of emotional memories: densitometry and statistical analysis
A. Vitelli-Rodríguez, I. Chévere, S. Peña de Ortíz and R. Chiesa
D203 Transcriptional control of Nramp1: a paradigm for the repressive action of c-Myc gene activationby Miz-1
A. Lapham, E. Phillips, H. Bowen and C.H. Barton
D204 In vitro conversion of liver to pancreas
W.-C. Li, J.M.W. Slack and D. Tosh
D205 Active repression of anti-apoptotic gene expression by RelA(p65) NF-kB induced by cytotoxic stimuli
K.J. Campbell, S. Rocha and N.D. Perkins
D206 Regulation of the CRD1 domain of p300/CBP by p21 WAF1/CIP1
E. Garcia Wilson and N. Perkins
D207 Classical protein kinase C, a role in NF-kB-dependent transcription?
N. Holden, P. Squires, C. Jones and R. Newton
D208 Synaptotagmin-11 expression is upregulated following differentiation of 3T3-L1 cells from fibroblast to mature adipocyte
S.C.M. Miller, J.M.C. Connell and G.W. Gould
D209 The transcription factor REST regulates KCNA3 gene expression in vascular smooth muscle cells
A.J. Bingham, A. Cheong, S.J. Fountain, B. Kumar, K.E. Porter, N.J. Buckley, D.J. Beech and I.C. Wood
D210 The role of FGF-2 and PKA in the differential response of fetal and adult human fibroblasts to TGF-b
C.C. Giannouli and D. Kletsas
D211 Poster Withdrawn
D212 Mutagenesis of hepatocyte nuclear factor-4a residues lining the dimerisation interface
P. Iordanidou, E. Aggelidou, C. Demetriades, O. Piltsi and M. Hadzopoulou-Cladaras
D213 Role of the transcription factor TFIIIC2 in regulation of transcription by RNA polymerase III
F. Cairns, P.H. Scott and R.J. White
D214 Establishment of an in vitro assay for excitotoxicity based on early response gene measurement in primary neuronal cells
A. Rogers, G. Schmuck, G. Scholz, R. Griffiths, C. Meredith and C. Williams
D215 Involvement of Prs polypeptides in cell integrity signalling and chromosome segregation
K. Wang, L.M. Schweizer and M. Schweizer
D216 The gelsolin-related flightless I protein is involved in intracellular signalling
S.A. Archer, C.A. Behm, C. Claudianos and H.D. Campbell
D217 Lipopolysaccharide and IkappaB kinase dependent induction of B cell translocation gene 2 (BTG2) expression
O. Sharif, P. Newham and N.D. Perkins
D218 Activation of RNA polymerase III transcription during cardiomyocyte hypertrophy
S.J. Goodfellow, R.J. White and P.H. Scott
D219 In vitro transcription:translation of alternatively-spliced calpastatin cDNAs
K.K. Jewell, C. Prevatt, T. Parr, P.L. Sensky, R.G. Bardsley and P.J. Buttery
D220 Regulation of RNA polymerase III transcription by mTOR
E.L. Graham, R.J. White and P.H. Scott
D221 Characterisation of mutations in the androgen receptor ligand binding domain found in prostate cancer
J. Duff and I.J. McEwan
D222 Regulation of nuclear factor kB (NFkB) by tumour necrosis factor (TNF)-a and histamine receptors
H.K. Warwick, R. Patel, S.R. Nahorski and R.A.J. Challiss
D223 Gene expression at the midblastula transition in zebrafish
S. McLoughlin, R.T. Bree, S. O’Boyle, M. Grealy and L. Byrnes
D224 Transcriptional regulations of the M2 muscarinic acetylcholine receptor
A. Krejci, A.W. Bruce, V. Dolezal, St. Tucek and N.J. Buckley
D225 Signalling pathways and calpastatin gene expression
K.J.P. Ryan, P.L. Sensky, K.K. Jewell, T. Parr, R.G. Bardsley and P.J. Buttery
D226 NF-kB transcription factor oscillations control the dynamics of target gene transcription
D.E. Nelson, D.G. Spiller and M.R.H. White
D227 Responsiveness of calpastatin promoters to cAMP- and Ca21-related stimuli
P.L. Sensky, K.K. Jewell, T. Parr, R.G. Bardsley and P.J. Buttery
D228 Crosstalk of the NF-kB and glucocorticoid signalling pathways
J. Johnson, C. Horton, G. Nelson, D. Spiller and M. White
D229 Lipopolysaccharide-induced haem oxygenase-1 expression in human monocytic cells is mediated by Nrf2
S.A. Rushworth and M.A. O’Connell

D301-D319 - DNA Repair and Checkpoints

Tuesday 20 July, 12:30-14:30
D301 Tyrosyl DNA phosphodiesterse interacts with DNA ligase III a and is involved in DNA single strand break repair
S.F. El-Khamisy, G.M. Saifi, J.R. Lupski and K.W. Caldecott
D302 Protein-protein interactions within the transcription-coupled repair apparatus
R.M. Albrighton and N.J. Savery
D303 Crystal structure of archaeal RadA to 3Ã… resolution
A. Ariza, D.J. Richard, M.F. White and C.S. Bond
D304 Investigating the physiological role of the Sgs1p helicase
H.W. Mankouri and I.D. Hickson
D305 Seckel syndrome cell lines exhibit defective ATR signaling
G. Alderton, M. O’Driscoll, J. Goodship and P. Jeggo
D306 Sulfolobus solfataricus XPF: an archaeal DNA repair nuclease
J. Roberts, J. Rudolf and M. White
D307 Properties of RadB from the halophilic archaeon, Haloferax volcanii
C.P. Guy and E.L. Bolt
D308 Protein dynamics on damaged DNA during base excision repair in human cell extracts
J.L. Parsons, I.I. Dianova and G.L. Dianov
D309 Functional analysis of the RecQ DNA helicase, Sgs1, with mismatch repair proteins in Saccharomyces cerevisiae
S. Bowen, A. Chaix and R. Borts
D310 Arabidopsis DNA double strand break repair pathways
C.E. West, W.M. Waterworth, P.A. Sunderland and C.M. Bray
D311 Holliday junction resolving enzymes from Sulfolobus solfataricus
J. Parker, C. Middleton, C. Bond and M. White
D312 Analysis of translation in cells undergoing DNA damage and apoptosis using cDNA microarray
I. Powley, M. Bushell, M. Stoneley and A.E. Willis
D313 Evaluation of the cytotoxicity of novel polyamine based anticancer agents
L. Ralton, C. Bestwick and P. Kong Thoo Lin
D314 Specific killing of BRCA2 deficient cells by inhibitors of poly(ADP-ribose) polymerase
H.E. Bryant, N. Schultz, H. Thomas, D. Flower, E. Lopez, S. Kyle, M. Meuth, N.J. Curtin and T. Helleday
D315 ATPase activities of the RuvB-like proteins TIP48 and TIP49 and their complex
T. Puri, B. Sigala and I. Tsaneva
D316 Sgs1, the yeast BLM orthologue, prevents recombination at damaged replication forks.
G. Maffioletti, M. Foiani and G. Liberi
D317 Use of novel two-dimensional substrate gel to separate RNase and DNase activities from Escherichia coli.
M. Hodskinson, L. Allen and J. Sayers
D318 Transcription enhances homologous recombination predominantly involving short tract gene conversion in mammalian cells
P. Gottipati, T. Cassel, L. Savolainen and T. Helleday
D319 Cofactor and substrate interactions in the FEN/DNA complex
M. Feng, D. Patel, A. Kilgour, J.J. Dervan, S. Haq and J.R. Sayers
D320 Comparative cytotoxicity of a cell penetrant mimetic of
R.D. Baker, J. Howl, and I. Nicholl
D321 Fission yeast Cdc23/Mcm10 in DNA replication and the cell cycle
S. Contini, J.A. Bryant and S.J. Aves
D322 An insight into the unusual bi-subunit DNA topoisomerase IB from Leishmania donovani
B.B. Das, N. Sen, A. Ganguly, and H.K. Majumder

D401-D403 - Nuclear RNA Splicing and Processing

Monday 19 July, 12:30-14:30
D401 Mammalian nucleolar protein Nap57 specifically interacts with DEAD RNA helicase p68
A.S. Kukalev, N.I. Enukashvily and O.I. Podgornaya
D402 Recognition sequences for the GYF domain reveal a possible spliceosomal function of CD2BP2
M. Kofler, K. Heuer, T. Zech and C. Freund
D403 HPV-16 regulates SF2/ASF and hnRNP A1 during epithelial cell differentiation
T. Veerapraditsin and S.V. Graham

D501-D503 - RNAi, How it Works and its Use as a Technology

Wednesday 21 July, 12:30-14:30
D501 Modulation of LXR expression using RNAi
A. Fisher, H. Davidson-Smith and D. Black
D502 RNAi in human primary cells via recombinant baculoviral vectors
L. Nicholson, M. Bertrand, A. Paine, D. Mann and C. Dolphin
D503 Modulation of GR expression using RNAi
B. McFerran, E. Grant and D. Black
D504 Assessing the importance of Gq/11a protein expression levels on single cell inositol 1,4,5-trisphosphate and Ca21 signalling mediated by mGlu1 and mGlu5 receptors using an RNAi approach
P.J. Atkinson, K.W. Young, S.J. Ennion, J.N.C. Kew, S.R. Nahorski and R.A.J. Challiss

D601-D605 - Cell Cycle Control

Monday 19 July, 12:30-14:30
D601 Dissection of the signalling mechanisms underlying FcgRIIb mediated apoptosis of mature B cells
N.A. Carter, D. Blair and M.M. Harnett
D602 Necrosis - a mode of controlled cell death regulated by proteolytic enzymes
A. Lichtenstein, L. Katz, O. Shpilberg and I. Nathan
D603 Cellular mechanisms of anti-tumor activity of aurintricarboxylic acid: study on HT29 human and MC38 murine colon carcinoma cells
L. Lichtenstein, A. Lichtenstein, M. Wolfson and V. Fraifeld
D604 Role of protein kinase C in the regulation of transcription by RNA polymerase III
E. Mauger, G.W. Gould and P.H. Scott
D605 The FHA domain protein SNIP1 is a regulator of the cell cycle and cyclin D1 expression
K.C. Roche, S. Rocha and N.D. Perkins

Focus Topic: Energy: Generation and Information

E101-E127 - Nutrient Interaction with Gene Expression

Tuesday 20 July, 12:30-14:30
E101 The role of hephaestin in dietary iron absorption
E. Aslan, B.A. Syed, S.K.S. Srai, R.W. Evans and K.N. White
E102 Deregulation of collagen a1(I) and lysyl oxidase gene expression in vitamin E-depleted colon
J.E. Drew, D.K. Mercer, C. Mayer, A.J. Farquharson, P.C. Morrice, J.R. Arthur and G.G. Duthie
E103 Oxidant regulation of Nramp1 via Sp1
I. Yeung, C.H. Barton and D.A. Mann
E104 Nrf2 and p38 mediate alpha lipoic acid-induced haem oxygenase-1 expression in THP-1 monocytes
R.M. Ogborne, S.A. Rushworth, C.A. Charalambos and M.A. O’Connell
E105 Impact of sterol response element binding protein-1c on insulin-containing secretory vesicle dynamics
L.E. Parton, E.R. Morley-Smith, F. Diraison, T. Tsuboi and G.A. Rutter
E106 Pro-inflammatory cytokine induced changes in nutrient metabolism in a clonal pancreatic beta-cell line
A. Kiely and P. Newsholme
E107 Analysis of non-esterified fatty acid induced changes in gene expression in BRIN-BD11 pancreatic beta-cell line
D. Keane and P. Newsholme
E108 Glutamine metabolism in the clonal pancreatic b cell line BRIN BD11
M. Corless and P. Newsholme
E109 Control of collagen cross-linking by telopeptide lysyl hydroxylase: the influence of vitamin C
C. Kimbembe, S.P. Robins, M.C. Wright and D.K. Mercer
E110 A putative amino acid transporter is involved in the catabolite repression of the dehalogenase of Burkholderia cepacia MBA4
H.F. Yuen and J.S.H. Tsang
E111 Transcriptional repression by shikonin involves inactivation of TATA box-binding protein in vivo
V. Staniforth, L.-T. Chiu and N.-S. Yang
E112 Reduced expression of HUVEC adhesion molecules by tocotrienol
M.S.A. Mutalib, H. Khaza’ai and L.S. Hui
E113 Proteomic analysis of dehalogenase producing Burkholderia cepacia
H.P.S. Wong and J.S.H. Tsang
E114 Apoptotic induction in cancer cell lines by traditional Chinese medicines
S. Willimott, E. Opara, L. Jones and J. Barker
E115 Effect of folate depletion during pregnancy and suckling upon DNA methylation in murine adult offspring
J.A. McKay, E.A. Williams and J.C. Mathers
E116 Conjugated linoleic acids (CLAs) downregulate cytokine expression in human umbilical vein endothelial cells
A.A. Sneddon and E. McLeod
E117 Microsatellite instability in mismatch repair proficient and deficient colorectal cancer cell lines exposed to butyrate
J.M. Coxhead, E.A. Williams, W. Bal, A. Curtis and J.C. Mathers
E118 Understanding the molecular basis of transcriptional control by an amino acid
A.D. Hughes and R.J. Reece
E119 Regulation of expression of AMP biosynthesis genes by SAICAR: an example of regulation of transcription by a small molecule
K. Rébora and R.J. Reece
E120 Grape seed procyanidins reduce plasma triglyceride and apoB48 in rat
J.M. Del Bas, M. Blay, J. Fernández, A. Ardévol, M.J. Salvadó, L. Arola and C. Bladé
E121 Grape seed procyanidin extract (GSPE) modulation of mRNA levels in glutathione peroxidase (GPx), glutathione reductase (GR) and glutathione S-transferase (GST)
F. Puiggròs, C. Bladé, A. Ardévol, L. Arola and M.J. Salvadó
E122 The importance of butyrate transport to the regulation of gene expression in the colonic epithelium
M. Cuff, J. Dyer, M. Jones and S. Shirazi-Beechey
E123 Grape-seed derived procyanidins alter adipogenic expression profile of 3T3-L1 cells
M. Pinent, M. Blay, J. Fernández, M.J. Salvadó, L. Arola, C. Bladé and A. Ardévol
E124 Production of multiple recombinant baculoviruses using robotic systems
E.A. Siaterli, R.B. Hitchman, C. Nixon, K. Richards, H. Irving, S. Mann, R.D. Possee and L.A. King
E125 Role of PI3K and MEK signal pathways in the induction of GST and UGT by sulforaphane in Caco-2 cells
Y. Bao, V. Svehlíková, J. Jakubíková and R. Mithen
E126 Liver hepcidin and transferrin receptor 2 expression in iron overload
M. Neonaki, K. White, C. Gove and A. Bomford
E127 Protein kinase C and Nrf2 mediate curcumin-induced ARE-regulated gene expression in THP-1 human monocytic cells
S.A. Rushworth, C.A. Charalambos, R.M. Ogborne and M.A. O’Connell
E128 SREBP-1 is involved in RXRa-independent retinoic acid stimulation of the fatty acid synthase (FAS) promoter
L. Zhang, M.C. Barber, M.T. Travers and M. Schweizer
E129 Gene expression profile of left ventricular myocardia from rats fed a diet enriched with olive oil
G. Harrison, F. Neaud and S. Somerset

E201-E211 - Redox and Transfer of Information

Wednesday 21 July, 12:30-14:30
E201 Poster Withdrawn
E202 Role of peroxynitrite and nitric oxide on the expression of TNF-alpha and IL-6 induced by extracorporeal circulation of blood
M.M. Elahi, B.M. Matata and M. Galiñanes
E203 Prion protein is ubiquitinated during scrapie infection
S.-C. Kang, D.R. Brown, M. Whiteman, R. Li, T. Pan, G. Perry, T. Wisniewski, M.-S. Syand B.-S. Wong
E204 Metabolism of tartrazine by haloperoxidase
L. Jervis and C. Northcott
E205 Poster withdrawn
E206 Structural and functional homologies of human proteolysis inducing factor
A.G. Lowrie, D.J. Wright, I.D. Waddell, S.J. Wigmore and J.A. Ross
E207 Novel 1,4-benzoquinone thioredoxin reductase inhibitors
J.A. Irwin, L. Thompson, J.P. Ryan, K. Murnaghan, G.G. Morgan and H.J. Windle
E208 DisR: a novel MerR-like regulator in Streptomyces coelicolor A(2)3 responds to disulfide stress
A. Chang and N.L. Brown
E209 Redox regulation of phosphatase function
N. Leslie, Y. Lindsay, S. Ross and P. Downes
E210 Reactive sulphur species in oxidative signal transduction
C. Jacob, J.R. Lancaster, Jr. and G.I. Giles
E211 Redox sensing in Kv1.7 channels
R.K. Finol-Urdaneta, N. Struever and H. Terlau
E212 Mitochondrial protein thiol modifications in response to nitric oxide donors
C.C. Dahm and M.P. Murphy

E301-E318 - Control and Sensing of Metabolism

Wednesday 21 July, 12:30-14:30
E301 An intelligent biochip “sniffs-out” tuberculosis in six hours
A. Pavlou, P. Klatser, N. Magan and A.P.F. Turner
E302 Involvement of 59-AMP-activated protein kinase (AMPK) in glucose sensing by hypothalamic neurons
P.D. Mountjoy, S.J. Bailey and G.A. Rutter
E303 Effect of L-carnosine on some hepatic antioxidants after ethanol intoxication
K.M. Soliman and N. Saba-El Rigal
E304 Prophylactic effect of Pulicaria crispa and Citharexylum quadrangylar jacq extracts on some liver enzymes representing different metabolic pathways in Schistosoma mansoni infected mice
M.A. Hamed, H.F. Aly, S.A. Aly and A.S. Maghraby
E305 Microgravity and cellular consequences in lymphocyte function
A. Sundaresan and N.R. Pellis
E306 Thrombin and histamine stimulate phosphorylation of endothelial NO-synthase via an Akt-independent, AMPkinase-dependent pathway
B. Thors, H. Halldorsson and G. Thorgeirsson
E307 Peroxidases controlling H2O2-mediated signalling and novel targets for drug design
M. Guo
E308 The interaction of Slt2 MAP kinase with members of the Prs protein family is essential for proper signal transduction through the cell wall integrity pathway in Saccharomyces cerevisiae
S. Vavassori, L. Schweizer and M. Schweizer
E309 Phenylalanine 4-monooxygenase and the S-oxidation of thioether substrates in the rat
A.H. Goreish, S. Bednar, H. Jones, S.C. Mitchell and G.B. Steventon
E310 Different expression profiles of the CYP1A1 and GSTM1 genes in carcinogenic and normal lung cell lines
K.K. Mohammed, R.W. Lea and A. Shervington
E311 The effect of different food processing methods on the total sugar content and the glycemic response of some West Indian foods
P.S. Bahado-Singh, A.O. Wheatley, E.St.A.Y. Morrison, M.H. Ahmad and H.N. Asemota
E312 Ringing the changes? Conservation of structure in DING proteins
K. Scott and L. Wu
E313 Abnormalities in Na1/K1 ATPase and monoamine oxidase enzymes during experimental diabetes in rat brain: control by Trigonella foenum graecum and sodium orthovanadate
M.R. Siddiqui, K. Moorthy, A. Taha, M.E. Hussain and N.Z. Baquer
E314 Alterations in antioxidant status in alloxan-diabetic skeletal muscle: effect of antidiabetic compounds
A. Taha, S. Mohd, M.R. Siddiqui, U.C.S. Yadav, S.F. Basir and N.Z. Baquer
E315 Identification of core metabolism using Python based software for interrogating annotated genomes
M.G. Poolman and D.A. Fell
E316 11 b-hydroxysteroid dehydrogenase type 1 - single or return fare?
R.A. De Sousa Peixoto, N.M. Morton, K.E. Chapman and J.R. Seckl
E317 Metabolic control analysis: application to a model of carbon metabolism in potato tubers
H.E. Assmus, M.G. Poolman and D.A. Fell
E318 Structural analysis of genomic scale metabolic models
B.K. Bonde , M.G. Poolman and D.A. Fell

Focus Topics: Ethics, Education and Employment

F101-F107 - Bioethics and Finance: Who Calls the Tune?

Tuesday 20 July, 12:30-14:30
F101 The extent of science communication activities undertaken by university based researchers in a post 1992 university
A.A. Morrison
F102 A bioethics course for bioscience students
J. Bryant and L. Baggott la Velle
F103 Incorporating on-line assessment and feedback into an integrated biochemistry course
Les Jervis and Loretta Jervis
F104 A survey into the provision of ethics teaching to bioscience undergraduates at UK Universities
C. Willmott, A. Bond, J. Bryant, S. Maw, H. Sears and J. Wilson
F105 Resources for teaching bioethics
C. Willmott, A. Bond, J. Bryant, S. Maw, H. Sears and J. Wilson
F106 Using webpage production to teach about bioethics
C. Willmott and J. Wellens
F107 The National Science Foundation teaching fellowship program at the University of Maine, USA: hands-on genetics in the public school classroom
C. Carrier, D. Stanhope, L. Gott, A. Masters, J. Gower and A. Cox
F108 Interactive drama as a tool in teaching bioethics
J. Somers and J. Bryant

Miscellaneous

G001-G039 - Miscellaneous

Wednesday 21 July, 12:30-14:30
G001 Empirical initial losses of dry matter from dacron bags determined by wallowing hay, straw and concentrates in artificial saliva buffer in vitro
J.P. Ryan, J. Mullally and T. Quinn
G002 Calculation of apparent initial losses of hay, straw and concentrates from dacron bags in ruminal fluid, with and without De-Odorase in vitro and in vivo, by extrapolation of dry matter degradation data
J.P. Ryan, J. Mullally and T. Quinn
G003 Purification and partial characterisation of goat milk xanthine oxidoreductase
D. Atmani and M. Benboubetra
G004 Anti-xanthine oxidoreductase activity from selected plants used in traditional medicine in Algeria
D. Atmani, H. Boudaoud, D. Atmani, M. Chibane and M. Benboubetra
G005 Circulating endothelial cell adhesion molecules: early markers for development of preeclampsiain diabetic pregnant women
H.O. El-Mosallamy
G006 Activation of vinculin binding site (VBS) in the talin rod involves rearrangement of a 5-helix bundle
E. Papagrigoriou, A. Gingras, I. Barshukov, D.R. Critchley and J. Emsley
G007 PPARg: a regulator of diverse cellular responses in childhood neuroblastoma
V.C. Emmans, H.A. Rodway, A. Hunt and K.A. Lillycrop
G008 Modulatory and beneficial effect of Coccinia indica on aortic collagen in streptozotocin-induced diabetic rats
L. Pari, S. Venkateswaran and G. Chandrakasan
G009 Nuclear import ability of African swine fever virus p10 and p14.5 proteins
I. Nunes-Correia, A. Eulálio, A.L. Carvalho, V. Citovsky, S. Simões, C. Faroand M.C. Pedroso de Lima
G010 No effect of dexamethasone on dex-ras1 mRNA human embryonic kidney (HEK 293) cells
G. Attarzadeh Yazdi, M.J. Shipston and F. Antoni
G011 Vascular endothelial growth factor stimulates AMP-activated protein kinase in endothelial cells
I. Sal and M.-A. Ewart
G012 Phenylalanine 4-monooxygenase and the S-oxidation of S-carboxymethyl-L-cysteine in the rat
B. Boonyapiwat, P. Panagopoulos, H. Jones, S.C. Mitchell, B. Forbes, and G.B. Steventon
G013 Exploring the structure-function paradigm for intrinsically unstructured proteins: SAXS and other studies with recombinant k-casein
R.A. Clegg and C. Holt
G014 The large sialidase from Clostridium perfringens: insights at atomic resolution
S. Newstead, C.-H. Chien, M. Taylor and G. Taylor
G015 In vitro digestibility of starches extracted from yams (Dioscorea spp.) grown in Jamaica: effect of granule size and crystallinity
C.K. Riley, A.O. Wheatley, M.H. Ahmad and H.N. Asemota
G016 The isolation of multi-potent adult progenitor cells (MAPC) from human bone marrow:comparison of methods
J. Pinxteren, D. Craeye, R. Raedt, A. Waeytens, J. Plum and B. Vandekerckhove
G017 Human recombinant indoleamine 2,3-Dioxygenase (hIDO)
N. Papadopoulou, M. Mewies and E.L. Raven
G018 Characterization of SARS main protease and inhibitor assay using a fluorogenic substrate
C.-J. Kuo, P.-F. Huang and P.-H. Liang
G019 Kinetics of expression of IL-1b and TNF-a Induced by drugs in alveolar macrophages of patients of bronchial asthma
M. Tyagi, V.K. Vijayan and S.K. Bansal
G020 Investigation of oxidation-antioxidation processes in erythrocytes and blood plasma exposed to blue light
V.A. Kudryavtsev, Y.P. Yelikova, P.I. Tsapok, A.A. Kosykh and O.I. Shilov
G021 Differential phosphorylation of the Hrs/Stam Complex
P.E. Row, M.J. Clague and S. Urbé
G022 Poster Withdrawn
G023 Functional characterization of the human metabotropic GABAB receptor complex
C. Nucci, S. Bovolenta and S. Corazza
G024 Proteolytic activity of melon seed extracts
C.M. Antão, F.X. Malcata and S. Gal
G025 Flexibility and function of an interaction site 2 of the complement receptor CR1
K. Bromek, D. Uhrin, M. Krych-Goldberg, J.P. Atkinson and P.N. Barlow
G026 Plant membrane trafficking and proteomics
T. Weimar, G.H.H. Borner and P. Dupree
G027 Protective immunity of multivalent DNA vaccine against Egyptian Schistosoma mansoni
M.A. Hanem, M.H. Romeih, T.S. Abou Shosha and M.A. Saber
G028 Fragment based discovery of inhibitors of p38 kinase
D. Davis, J. Curry, A. Gill, M. Vincovic and H. Jhoti
G029 Role of lipid rafts in export of cholesterol from macrophages
K. Gaus, L. Kritharides and W. Jessup
G030 Novel RNA isolation technology resulting in high-purity bacterial RNA
C.A. Robbins
G031 Intracellular transport of CYP51 protein in mammalian cells
M. Cotman, D. Je?zek, R. Frange?z and D. Rozman
G032 Regulation of glutamate formation and activities of glutamate dehydrogenase by Cimicifuga heracleifolia in cultured islets
S.-W. Cho, S.-J. Yang, J.-W. Huh, H.-J. Lee and M.-M. Choi
G033 Janus Kinase 2 is involved in bovine growth hormone generation of cytosolic free Ca21 oscillations in single rat hepatocytes
I. Marrero and A. Déniz
G034 Stereoselectivity of Burkholderia cepacia lipase towards secondary alcohols
S. Tomi´c, B. Berto?sa and B. Koji´c-Prodi´c
G035 Formation of plasma lipid peroxides in adult and suckling rats treated with menadione
H. Ansarihadipour and A. Allameh
G036 AKAP-anchored PDE4 isoforms regulate basally active PKA in COS1 cells
A. McCahill, T. McSorley, E. Huston and M.D. Houslay
G037 Structural investigation of Spred function
N.J. Harmer and T.L. Blundell
G038 The Role of Pak1 in the developing cortex
D. Worth, K. Philpott and M. Nikolic
G039 Leptin as a pro-inflammatory cytokine: induction of lipid body formation and leukocyte activation
C.M. Maya-Monteiro, A.P. Rezende, H. D’Ávila, P.E. de Almeida, H.C. Castro-Faria-Netoand P.T. Bozza
G040 Lipidomic evaluation of acyl chain-based refinement in the molecular selectivity for membrane phospholipids bound to recombinant phosphatidylinositol transfer protein alpha (PITPa)
A.N. Hunt, A.J. Skippen, G. Koster, A.D. Postle and S. Cockcroft
G041 Properties of a pectin-xyloglucan complex formed in the pea Golgi apparatus
H.D. Rizkallah, E.A.-H. Baydoun and C.T. Brett
G042 Analysis of a putative ER retention sequence in the carboxy terminus of the extracellular calcium-sensing receptor
D. Maldonado-Pérez and D. Riccardi
G043 Interactions between PKC and F-box WD40 proteins
J. Durgan, X. Iturrioz, K. Nakayama and P.J. Parker

Research Colloquia

R101-R112 - Lipidomics in Heath and Disease: New Technologies in Lipid Analysis

Monday 19 July, 12:30-14:30
R101 Lipid rafts, Ca signalling and contractility: an investigation in human uterus
J. Zhang, A. Kendrick, M. Tattersall, S. Quenby and S. Wray
R102 Targeting phospholipase A1 in African trypanosomes
G.S. Richmond and T.K. Smith
R103 Identification of a Trypanosoma brucei phoshatidylinositol synthetase
K.L. Martin and T.K. Smith
R104 Mass spectroscopic analysis of phosphatidylinositol synthesis using 6-deuteriated-myo-inositol: comparison of the molecular specificities and acyl remodelling mechanisms in mouse tissues and cultured cells
A.D. Postle, H. Dombrowsky, H. Clarke, C.J. Pynn, G. Koster and A.N. Hunt
R105 Lipidomic analysis of the molecular specificity of a cholinephosphotransferase
A.N. Hunt, H.C. Fenn, G.T. Clark, M.M. Wright, A.D. Postle and C.R. McMaster
R106 Signalling pathways involved in lysophosphatidlycholine induced phospholipase D activation in human endothelial cells
S. McHarg, A.C. Shore and J.L. Whatmore
R107 Use of mass spectrometry-based lipidomics to probe phosphatidylinositol transfer protein a (PITPa) function inside the nuclei of PITPa1/1 and PITPa2/2 cells
A.N. Hunt, J.G. Alb, G. Koster, A.D. Postle and V.A. Bankaitis
R108 Analysis of the molecular specificity of neutrophil phospholipase D by electrospray ionisation mass spectrometry
G. Jewell, G. Koster, N. Henderson and A.D. Postle
R109 Dynamics and molecular specificity of [methyl-D9] choline incorporation into liver and plasma phosphatidylcholine in mice
N.G. Henderson, H. Clark, K.B. Reid, G. Koster and A.D. Postle
R110 Is membrane PtdCho turnover altered in the neutrophils of cystic fibrosis patients?
I. Dash, N.G. Henderson, P.M. Hockey, G. Koster and A.D. Postle
R111 Kinetics of human plasma phosphatidylcholine synthesis by the CDP:choline and N-methyltransferase pathways in vivo
C.J. Pynn, W. Bernhard and A.D. Postle
R112 Which PE is utilised by the T. brucei GPI biosynthetic pathway?
T.K. Smith, J.A. Nunes, K.L. Martin and G.S. Richmond
R113 The G534M mutant of peroxisomal carnitine octanoyltransferase catalyses acetyl transfer only
N. Sitheswaran, N.T. Price and R.R. Ramsay

R201-R208 - Mitochondria in Health and Disease

Monday 19 July, 12.30-14.30
R201 Study of the prostaglandin receptors in mitochondria on apoptosis of human lung carcinoma cell line A549
K.-M. Fang, W.-H. Shu, H.-C. Chang, J.-J. Wang and O.-T. Mak
R202 Cell-penetrating peptides as vectors for delivery to mitochondria
M.F. Ross, M.J. Gait and M.P. Murphy
R203 Resveratrol attenuates hyperosmotic shock-induced apoptotic biochemical changes in human hepatoma 3B cells
W.-H. Chan
R204 Selective elimination of mitochondria from living cells induced by inhibitors of bioenergetic functions
K.G. Lyamzaev, O.Y. Pletjushkina, V.B. Saprunova, L.E. Bakeeva, F. Yang, B.V. Chernyakand V.P. Skulachev
R205 Functional characterisation of a novel JNK-interacting protein
C. Wiltshire, D.A.F. Gillespie and G.H.W. May
R206 Inhibition of mitochondrial respiration by the anticancer agent 2-methoxyestradiol and its consequences for HIF1a stabilisation and cellular ROS production
T. Hagen, G. D’Amico, M. Quintero and S. Moncada
R207 Identification of a functioning mitochondrial uncoupling protein 1 in rat thymus
A.M. Carroll, L.R. Haines, T.W. Pearson, C. Brennan, E. Breen and R.K. Porter
R208 Inflammatory-activated microglia kill co-cultured neurons via nitric oxide and peroxynitrite
P. Mander and G. Brown

R301-R305 - Mechanisms of Gene Regulation

Monday 19 July, 12:30-14:30
R301 Map Kinase Phosphatase-2 (MKP-2) gene regulation in cardiac hypertrophy
J. Kodituwakku, N. Brand and S. Fuller
R302 Characterisation of the SARS coronavirus 1a/1b ribosomal frameshifting signal
F. Dos Ramos, M. Carrasco, T. Doyle and I. Brierley
R303 Differential effects of fluoroquinolone antibiotics on metalloproteinase gene expression in human tendon cells
A.N. Corps, R.L. Harrall, V.A. Curry, B.L. Hazleman and G.P. Riley
R304 Poster Withdrawn
R305 In vitro regulation of reporter gene transcription by the androgen receptor AF1 domain
M.A. Choudhry and I.J. McEwan

R401-R409 - Control of Cell Motility

Wednesday 21 July, 12:30-14:30
R401 BPGAP1 interacts with cortactin and facilitates its translocation to cell periphery for enhanced cell migration
B.L. Lua and B.C. Low
R402 Regulation of the actin cytoskeleton by the Rho GTPase, Rif
S. Pellegrin, S. Passey, S. Ellis and H. Mellor
R403 Differences in expression between gliomas and meningiomas of proteins involved in tumour invasion and peritumoural oedema
A.T. Panagopoulos, P.H.P. Aguiar and A. Colquhoun
R404 Immunocytochemical localisation of molecules involved in glioma cell migration in vivo
J.A. Miyake and A. Colquhoun
R405 mRNA expression of proteins related to cell cycle, invasion and angiogenesis in the C6 rat glioma modelin vivo
M. Benadiba and A. Colquhoun
R406 Flow cytometry monitoring of cell recruitment into syncytia induced by HIV-envelope expressing cells
L. Huerta, N. López, C. Villarreal, E. Rivera, E. Lamoyi and C. Larralde
R407 Functional analysis of WspR, a GGDEF response regulator
J.G. Malone, A.J. Spiers and P.B. Rainey
R408 A PLCd1-binding protein, p122RhoGAP, is localized in focal adhesions.
K. Kawai, M. Yamaga, Y. Iwamae, M. Kiyota, H. Kamata, H. Hirata and H. Yagisawa
R409 Immunohistochemical localization of proteins related to differentiation, migration and angiogenesis in the C6 rat glioma model
K.L. Ramos and A. Colquhoun
R410 The activation of PI(4)P 5Kinase-a by diacylglycerols
B. Pérez-Mansilla and G.M.H. Thomas
R411 Ezrin/Radixin/Moesin (ERM) proteins regulate microvillar positioning of L-selectin and leukocyte capture from flow
A. Ivetic, O. Florey, J. Deka, D. Haskard, A. Ager and A.J. Ridley
R412 Control of SCAR activity in Dictyostelium discoideum
S.L. Blagg and R.H. Insall

R601-R613 - Proteins Acting at or in Membranes: Structure and Function Update

Thursday 22 July, 12:30-13:30
R601 The relationship between membrane binding and aggregation of a-synuclein peptides
J. Madine, D.A. Middleton and A.J. Doig
R602 COX-2 induction following signalling through CD44 on endothelial cells.
F. Lennon, J. Murphy, D. Kelleher, D. Fitzgerald and A. Long
R603 FRET analysis reveals in planta dynamics of the MLO-calmodulin interaction during fungal pathogenesis
R. Bhat, P. Schulze-Lefert and R. Panstruga
R604 Novel strategies for the identification of Neisseria meningitidis ligands for the class A macrophage scavenger receptor
L. Peiser, A. Plüddemann and S. Gordon
R605 The cacophony gene and courtship song: GAL4-driven expression of UAS-cac in Drosophila melanogaster
A.J. Cox, H.B. Dowse and J.C. Hall
R606 Effect of hypoxia and hypoxic preconditioning on brain metalloproteinases
N. Nalivaeva, E. Rybnikova, L. Fisk, A. Galeeva, E. Tulikova, N. Makava, A. Huovila, M. Pelto-Huikko,A.J. Turner and M. Samoilov
R607 Annexin II expression during cellular differentiation in myeloid cell lines
W.S. Gilmore, S. Olwill, H. McGlynn and H.D. Alexander
R608 Overexpression of ZO-1 in retinal pigment epithelial cells: effects on permeability
M. Campbell and B. Brankin
R609 Activity, expression and localization of neprilysin in human neuroblastoma NB7 cells after hypoxia and oxidative stress
L. Fisk, K. Rassmussen, N. Nalivaeva and A.J. Turner
R610 Lymphocyte activation receptors: new structural paradigms in the group V of C-type animal lectins
J. Pavlicek, R. Ettrich, V. Kopecky, P. Man, M. Vrbacky and K. Bezouska
R611 Poster Withdrawn
R612 Encephalopathic neuronal [Prion] proteins, transfer factors of delayed-type hypersensitivity [DTH] and transmissible proteinaceous infection: structural relations in protein folding and domains for binding redox- and metalloregulated nucleic acid bioaptamers
J.H. Wissler
R613 Structure and function of a protein-conducting channel
I. Collinson
R614 Connexin-43-interacting proteins involved in its transport, stabilization at the plasma membrane and degradation
E. Butkevich, A. Alovskajya, T. Shirao, S. Hülsmann, R. Duden and I. Majoul
R615 Mammalian cell entry (Mce) proteins encoded by mce3 operon of Mycobacterium tuberculosis are expressed during natural infection in humans
S. El-Shazly, S. Ahmad and A.S. Mustafa
R616 Mutations in the RANK signal peptide alter the subcellular localisation of RANK and ligand-dependent activation of NFkb
J. Crockett, S. Ralston and M. Rogers

R701-R704 - GPCR - Ion Channel Interactions

Tuesday 20 July, 12:30-14:30
R701 The role of the N-terminus of voltage-gated calcium channels in the inhibition by G-proteins
L. Wheat, W.S. Pratt, C. Canti, K.M. Page and A.C. Dolphin
R702 Phosphatidylinositol 3 Kinase enhances the trafficking of functional Cav/b2 channels to the plasma membrane.
P. Viard, A.J. Butcher, G. Halet, A. Davies, B. Nürnberg, F. Heblich and A.C. Dolphin
R703 Preferential regulation of G-protein activation by RGS8 is indicative of complex interactions
A. Benians, M. Nobles and A. Tinker
R704 Enhancement of single-cell protein expression using SV40 large T antigen in HEK-293S cells
Z. Huang, G. Li, W. Pei, L.A. Sosa and L. Niu